Results 191 to 200 of about 87,932 (259)

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Cultivando ecosistemas empresariales sostenibles: cómo la creatividad transforma la motivación en actitudes emprendedoras entre los estudiantes universitarios de primer año. [PDF]

F1000Res
Arbulú Ballesteros MA, Vera Calmet VG, Otiniano León MY, Aguilar Armas HM, Guzmán Valle MLÁ, Alegría Silva CE.   +5 more
europepmc   +1 more source

AI‐Physics‐Experiment Trinity for Integrated Protein Dynamics Modeling

Advanced Science, EarlyView.
This review unites experiments, physics‐based simulations, and AI as a synergistic triad for protein dynamics modeling. It highlights integrative strategies, resolves sampling and forcefield bottlenecks, and outlines challenges and future directions for accurate, interpretable conformational ensemble prediction.
Chen Shi, Minying Low, Peng Xiu, Kresten Lindorff‐Larsen, Yong Wang   +4 more
wiley   +1 more source

The association between reading anxiety and reading achievement: A meta-analysis and systematic review. [PDF]

Psychol Bull
Johnson RM, Schaefer M, Norris CU, Wagner RK, Hart SA.   +4 more
europepmc   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

The Subjective Assessment Paradox in Health Literacy: Implications for Intervention Design in Primary Care Settings. [PDF]

Health Sci Rep
Qingfei K, Wen X.
europepmc   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

The cognitive foundations of STEM achievement: a cross-national multilevel and SEM investigation. [PDF]

Front Psychol
Metli A.
europepmc   +1 more source

Motivational pathways from perceived teacher support to student engagement in EFL classes. [PDF]

Front Psychol
Zhang X, Kim HJ.
europepmc   +1 more source

Positive emotions in fairy-tale reading: a text-mining study of nostalgia among adult purchasers from 1,428 online reviews. [PDF]

Front Psychol
Liu C, Feng T, Wang J.
europepmc   +1 more source