Results 191 to 200 of about 88,488 (260)

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Educational Trajectories and Academic Achievement from Primary to Secondary Education: A Systematic Review of Individual, Family, School, and Contextual Factors. [PDF]

Behav Sci (Basel)
Salvo-Garrido S, Polanco-Levicán K, Cisternas-Salcedo P, Moraga-Pumarino A.   +3 more
europepmc   +1 more source

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

Advanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian, Yalan Wan, Chen Chen, Xiaoyu Zheng, Wenjing Du, Junhan Yang, Zhihao Quan, Biyu Yang, Jiaxi Yu, Jie Zheng, Zhaoxia Wang, Jianwen Deng, Qiang Guo   +12 more
wiley   +1 more source

Growth mindsets are less endorsed and less associated with academic performance in non-WEIRD cultures. [PDF]

NPJ Sci Learn
Wang Y, Tang X, Wu S, Sun X.
europepmc   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Chinese as a second language anxiety and intervention in a technology-assisted environment: a mini-review. [PDF]

Front Psychol
Yu B.
europepmc   +1 more source

The Reading Motivators Analysis of the Secondary Students and Development of Reading Motivation Improvement Program

Journal of CheongRam Korean Language Education, 2008
openaire   +1 more source

Enhancing attention and emotion regulation in children with ADHD through AR digital picture books: a structural equation modeling approach. [PDF]

Front Psychol
Yang R, Sun W, Liu X, Cao Y.
europepmc   +1 more source

Evaluating AI-Generated Podcasts Versus Traditional Reading for Learning From Medical Articles: Protocol for a Mixed-Design Study Among Resident Physicians. [PDF]

JMIR Res Protoc
Stadler M, Richters C, Fischer MR, Hutmacher F.   +3 more
europepmc   +1 more source

From Predictors to Mechanisms: Interpretable Artificial Intelligence Evidence on Mathematics Achievement and Cognitive Learning Systems. [PDF]

J Intell
Meng D, Wan ATK.
europepmc   +1 more source