Results 111 to 120 of about 1,043,587 (318)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

Visual Words for Automatic Lip-Reading [PDF]

open access: yesPhD thesis, the University of Buckingham, 2009, 2014
Lip reading is used to understand or interpret speech without hearing it, a technique especially mastered by people with hearing difficulties. The ability to lip read enables a person with a hearing impairment to communicate with others and to engage in social activities, which otherwise would be difficult.
arxiv  

A GLIMPSE ON THE BESTSELLER READING PROCESS

open access: yesTravessias, 2008
This work intends to discuss the bestseller concept, relating aspects on the cultural industry and concluding with the performance analysis of a well-know bestseller Brazilian writer, Lus Fernando Verssimo.
Arnaldo Cortina   +1 more
doaj  

The Ambiguities of an Ambiguity-Reading: A Critical Reading of The Function of Ambiguity in the Process of Reading [PDF]

open access: yesپژوهش‌نامۀ انتقادی متون و برنامه‌های علوم انسانی, 2018
As a communicative-epistemological concept, ambiguity is pivotal to any discussion of reading. Due to its roots in different fields of knowledge, as well as its dependence on age, genre, style, etc., ambiguity finds different embodiments in different ...
Parsa Janbeh Saraie
doaj  

Some temporal characteristics of processing during reading. [PDF]

open access: green, 1985
George W. McConkie   +3 more
openalex   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

Sviluppare Competenze per Creare Test di Comprensione della Lettura Arricchiti da Domande a Scelta Multipla

open access: yesAleph
On the timeline of the development of reading, the real revolution was marked by the rise of structural cognitivism in the 1970s, anticipating another breakthrough that would result from artificial intelligence.
Abdelhalim Melzi
doaj  

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

open access: yesMolecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen   +17 more
wiley   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

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