Results 111 to 120 of about 102,669 (304)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Teachers\u27 reading promotion activities: Variation, structure and correlates
, 2020 The purpose of this study is to determine which different forms of reading promotion activities teachers perform in fifth and sixth grade in The Netherlands and whether different forms of reading promotion activities are acted out independently or ...
van Schooten, Erik +2 more
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BiD: Textos Universitaris de Biblioteconomia i Documentació, 2019 En aquest article es presenta un recull d'experiències per a promoure la prescripció lectora a la biblioteca Xavier Benguerel de Barcelona que s’han dut a terme durant els darrers cinc anys. S'explica quins són els tipus de fons i els usuaris als quals s'
Azuara González, César +1 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
An evaluation of the Cheshire Sexual Health Promotion project [PDF]
, 2005 This project report discusses an evaluation study of the Sexual Health Promotion project in Cheshire, which ran from 2000 to 2004.The project was commissioned by the steering group of the Sexual Health Promotion project and funded by South Cheshire ...
Killey, Mona +2 more
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Conspirant a favor de la lectura : clubs de lectura i rutes literàries
BiD: Textos Universitaris de Biblioteconomia i Documentació, 2019 Aquest article recull l'experiència de dues sessions programades per a la primera edició del postgrau de Prescripció Lectora impartit, l'any 2017, a la Facultat de Biblioteconomia i Documentació de la Universitat de Barcelona.
Mulet Cugat, Gemma
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Reading Promotion: Conceptual Models and Category Frameworks Analysis
, 2018 This paper is a translation of the Study on the Concept and Scope of Reading Promotion by Youhua Chen, initially published in Chinese in the Library Journal, 2017,36(04):19 - 24+18.DOI:10.13663/j.cnki.lj.2017.04.003.
Chen, Youhua, Huang, Qingling, Wu, Jane
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source