Results 121 to 130 of about 102,669 (304)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
University Bookstores and the Promotion of Reading
Bibliographica, 2021 The university press production derives from research, teaching and dissemination activities undertaken at its campuses. This generates an offer of highly specialized editions, which results in a small number of potential readers, almost all researchers, professors and students from the university itself.
openaire +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
The purpose of this study is to examine approaches to book reading (Thorson, 1988), how they can present in book promotion and how they can interact with elements of the reading circle (Chambers, 2011).
Jerszynska, Anna
core
An introduction : population health and health promotion
, 2009 After reading this chapter, readers will be able to: understand definitions of key terms in population health and health promotion -- explain the development of models of health and evaluate the application of these models in different settings and ...
Jirojwong, Sansnee (R12139) +1 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
A benefit congruency framework of sales promotion effectiveness [PDF]
Are monetary savings the only explanation for consumer response to a sales promotion ? If not, how do the different consumer benefits of a sales promotion influence its effectiveness ?
CHANDON, Pierre +2 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Reading promotion actions for kids
, 2013 Bakalaura darbā pētīti bērnu lasīšanas veicināšanas pasākumi un bērna motivācija lasīt. Darba mērķis ir apzināt un analizēt šo pasākumi ietekmi uz bērniem, efektivitāti lasīšanas veicināšana un bērnu attieksmi pret tiem. Bērni ir lietotāju grupa, kurai
Vaivode, Sigita
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source