Results 101 to 110 of about 20,721,734 (308)

Real-time Triple-modal Photoacoustic, Ultrasound, and Magnetic Resonance Fusion Imaging of Humans

, 2019
Imaging that fuses multiple modes has become a useful tool for diagnosis and therapeutic monitoring. As a next step, real-time fusion imaging has attracted interest as for a tool to guide surgery.
Kim, Chulhong, Kim, Young Soo, Park, Sara, Jang, Jongseong, Kim, Jeesu   +4 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Image denoising for real‐time MRI

Magnetic Resonance in Medicine, 2016
PurposeTo develop an image noise filter suitable for MRI in real time (acquisition and display), which preserves small isolated details and efficiently removes background noise without introducing blur, smearing, or patch artifacts.Theory and MethodsThe proposed method extends the nonlocal means algorithm to adapt the influence of the original pixel ...
Klosowski, J., Frahm, J.
openaire   +4 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Real-time terahertz imaging with a single-pixel detector

Nature Communications, 2020
Terahertz imaging is promising in many applications, but still relies on complex equipment. Here, the authors develop a simplified solution that enables terahertz real-time imaging using a single-pixel detector and rapid reconstruction methods.
Rayko Ivanov Stantchev, Xiao Yu, Thierry Blu, Emma Pickwell-MacPherson   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Real-time and high-resolution magnetic particle optical imaging

Magnetic nanoparticles (MNPs) have emerged as a promising medical imaging contrast agent due to their nontoxic and non-invasive properties, among others. This suggests that they possess significant potential for future applications.
Liu, Wenzhong, Cui, Xinchao
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Image stitching for real-time laparoscopic hyperspectral imaging

Scientific Reports
Hyperspectral imaging (HSI) shows significant promise in the medical field for tissue detection and perfusion assessment. To extend its application to intraoperative diagnosis, laparoscopic cameras combining a high resolution color video and simultaneous
Marie-Sophie von Braun, Annekatrin Pfahl, Andreas Melzer, Claire Chalopin, Hannes Köhler   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source