Results 71 to 80 of about 20,721,734 (308)

Real-time imaging of HIF-1alpha stabilization and degradation. [PDF]

PLoS ONE, 2009
HIF-1alpha is overexpressed in many human cancers compared to normal tissues due to the interaction of a multiplicity of factors and pathways that reflect specific genetic alterations and extracellular stimuli.
Ekaterina Moroz, Sean Carlin, Katerina Dyomina, Sean Burke, Howard T Thaler, Ronald Blasberg, Inna Serganova   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Towards an HLA Run-time Infrastructure with Hard Real-time Capabilities [PDF]

, 2010
Our work takes place in the context of the HLA standard and its application in real-time systems context. The HLA standard is inadequate for taking into consideration the different constraints involved in real-time computer systems.
Adelantado, Martin, Siron, Pierre, Chaudron, Jean-Baptiste   +2 more
core  

Noninvasive real-time imaging of apoptosis [PDF]

Proceedings of the National Academy of Sciences, 2002
Strict coordination of proliferation and programmed cell death (apoptosis) is essential for normal physiology. An imbalance in these two opposing processes results in various diseases including AIDS, neurodegenerative disorders, myelodysplastic syndromes, ischemia/reperfusion injury, cancer, autoimmune disease, among others ...
Bharathi, Laxman, Daniel E, Hall, Mahaveer Swaroop, Bhojani, Daniel A, Hamstra, Thomas L, Chenevert, Brian D, Ross, Alnawaz, Rehemtulla   +6 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Virtualised e-Learning with Real-Time Guarantees on the IRMOS Platform1 [PDF]

, 2010
In this paper we focus on how Quality of Service guarantees are provided to virtualised applications in the Cloud Computing infrastructure that is being developed in the context of the IRMOS1 European Project. Provisioning of proper timeliness guarantees
Boniface, M, Z. Zlatev, Voith, T, Stein Manuel, Papay, Jury, Berger, Sören, Cucinotta, T, Lamp, D, Voith, Thomas, Mazzetti, A, CUCINOTTA, TOMMASO, T. Voith, Varvarigou, Theodora, M. Boniface, A. Mazzetti, Papay, Juri, G. Kousiouris, T. Cucinotta, D. Kyriazis, Kyriazis, D, S. Berger, Mazzetti, Alessandro, Kyriazis, Dimosthenis, J. Papay, Boniface, Michael, Lamp, Dominik, Varvarigou, T, Checconi, Fabio, D. Lamp, Kousiouris, George, Berger, S, Zlatev, Z, M. Stein, Zlatev, Zlatko, T. Varvarigou, Boniface, Mike, Stein, M, Papay, J, F. Checconi, Kousiouris, G, Checconi, F   +40 more
core   +2 more sources

Real‐Time In Vivo Cellular‐Level Imaging During Puncture

Advanced Science
In the pursuit of precise disease diagnosis, accurate tissue sampling during biopsy is critical. Current CT/ ultrasound‐guided biopsies provide macroscopic localization but lack real‐time cellular‐resolution visualization during puncture, particularly ...
Huifang Gao, Jiakang Shao, Quanzhi Li, Yizhou Tan, Liangliang Huang, Xiaorong Xu, Ji Qi, Julin Xiao, Wenwen Li, Zhong Wen, Le Wang, Xu Liu, Qing Yang, Ying Gu   +13 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Real-time imaging of sulfhydryl single-stranded DNA aggregation

Communications Chemistry, 2023
The structure and functionality of biomacromolecules are often regulated by chemical bonds, however, the regulation process and underlying mechanisms have not been well understood.
Fanwei Zeng, Youhong Jiang, Nana He, Tiantian Guo, Tiqing Zhao, Mi Qu, Yue Sun, Shuting Chen, Dan Wang, Yong Luo, Guangwen Chu, Jianfeng Chen, Shi-Gang Sun, Hong-Gang Liao   +13 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source