Results 81 to 90 of about 21,652,291 (267)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Precise Pitch Control in Real Time Corpus-Based Concatenative Synthesis [PDF]

, 2012
The need for fine-tuned microtonal pitch combined with the timbral richness of corpus-based concatenative synthesis has led to the development of a new tool for corpus-based pitch and loudness control in real time with CATART.
Trapani, Christopher, Schwarz, Diemo, Einbond, Aaron   +2 more
core   +4 more sources

Stabilizing REGARD with real-time MCMC uncertainty quantification and precise point positioning

Earth, Planets and Space
This study introduces structural upgrades to REGARD, Japan’s real-time GNSS-based coseismic analysis system, addressing two long-standing limitations in real-time geodetic source modeling: the absence of explicit uncertainty quantification in fault ...
Keitaro Ohno, Satoshi Abe, Naofumi Takamatsu, Takayuki Miyazaki, Koki Yoshinaga, Chinami Shodai, Mayumi Hashimoto, Riku Yamamoto, Satoshi Kawamoto, Yusaku Ohta   +9 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Recent Advances in Wide Area Real-Time Precise Positioning [PDF]

TransNav, 2011
This paper describes briefly new high precision wide area real time positioning systems, discusses their evolution, implementation and presents recent results.
Dariusz Lapucha, K. de Jong, X. Liu, T. Melgard, O. Oerpen, E. Vigen   +5 more
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Integrated real-time precise point positioning system with B2b/B2a/B1C services

Satellite Navigation
Real-Time Precise Point Positioning (RTPPP) technology is one of the most important means of positioning and navigation, whereas this type of service requires Internet access.
Zhetao Zhang, Hao Wang, Yuanxi Yang
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source