Results 41 to 50 of about 1,045,423 (310)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

HLA high performance and real-time simulation studies with CERTI [PDF]

, 2011
Our work takes place in the context of the HLA standard and its application in real-time systems context. Indeed, current HLA standard is inadequate for taking into consideration the different constraints involved in real-time computer systems.
Adelantado, Martin, Noulard, Eric, Chaudron, Jean-Baptiste, Siron, Pierre   +3 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Towards an HLA Run-time Infrastructure with Hard Real-time Capabilities [PDF]

, 2010
Our work takes place in the context of the HLA standard and its application in real-time systems context. The HLA standard is inadequate for taking into consideration the different constraints involved in real-time computer systems.
Adelantado, Martin, Siron, Pierre, Chaudron, Jean-Baptiste   +2 more
core  

Experimental evaluation of the seismic performance of steel MRFs with compressed elastomer dampers using large-scale real-time hybrid simulation [PDF]

, 2011
Real-time hybrid simulation combines experimental testing and numerical simulation, and thus is a viable experimental technique for evaluating the effectiveness of supplemental damping devices for seismic hazard mitigation.
Karavasilis, Theodore L., Ricles, J.M., Ricles, James M., Sause, R., Sause, Richard, James M. Ricles, Chen, Cheng, Theodore L. Karavasilis, Richard Sause, Cheng Chen, Karavasilis, T.L., Chen, C.   +11 more
core   +1 more source

Analysis of Real-Time Applications Feasibility through Simulation

Моделирование и анализ информационных систем, 2016
An approach to estimate feasibility of a real-time multi-task application with various combinations of the scheduling mode and the protocol of access to shared informational resources when run on a multi-core platform is described.
S. N. Baranov, V. V. Nikiforov
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Real-Time Operating System Modelling and Simulation Using SystemC [PDF]

, 2010
Increasing system complexity and stringent time-to-market pressure bring challenges to the design productivity of real-time embedded systems. Various System-Level Design (SLD), System-Level Design Languages (SLDL) and Transaction-Level Modelling (TLM ...
Yu, Ke
core