Results 51 to 60 of about 20,202,611 (293)
Dynamic average modelling of renewable generation sources for real time simulation
The Journal of Engineering, 2019 The increase in microgrids and smart grid research comprising renewable generation sources with advanced grid control functionalities is driving the need for sophisticated simulation and hardware in the loop (HIL) test facilities using digital real time ...
Onyinyechi Nzimako +2 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Survey of Finite Element Method-Based Real-Time Simulations
Applied Sciences, 2019 The finite element method (FEM) has deservedly gained the reputation of the most powerful, highly efficient, and versatile numerical method in the field of structural analysis.
Dragan Marinkovic, Manfred Zehn
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Real-Time Incompressible Fluid Simulation on the GPU
International Journal of Computer Games Technology, 2015 We present a parallel framework for simulating incompressible fluids with predictive-corrective incompressible smoothed particle hydrodynamics (PCISPH) on the GPU in real time. To this end, we propose an efficient GPU streaming pipeline to map the entire
Xiao Nie, Leiting Chen, Tao Xiang
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Real-Time Million-Synapse Simulation of Rat Barrel Cortex
Frontiers in Neuroscience, 2014 Simulations of neural circuits are bounded in scale and speed by available computing resources, and particularly by the differences in parallelism and communication patterns between the brain and high-performance computers.
Thomas eSharp +3 more
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Distributed Simulation of Heterogeneous and Real-time Systems [PDF]
, 2013 This work describes a framework for distributed simulation of cyber-physical systems (CPS). Modern CPS comprise large numbers of heterogeneous components, typically designed in very different tools and languages that are not or not easily composeable ...
Lasnier, Gilles +9 more
core +1 more source
Real-time Simulation of Electric Switch
机车电传动, 2012 Idealized simulation modeling methods for electric switch were studied. Possible existing stiff problem and signals transmitting logical conflict problem were settled by simple means.
ZHANG Yu +4 more
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