Results 1 to 10 of about 1,529,109 (298)

Real-World Analysis of Clinical Characteristics, Treatment Patterns, and Patient-Reported Outcomes of Insufficient Responders and Responders to Prescribed Acute Migraine Treatment in China

Pain and Therapy, 2023
Introduction Migraine is a common disabling primary headache disorder characterized by attacks of severe pain, sometimes accompanied by symptoms including nausea and photo-/phono-phobia.
Lei Zhang, Diego Novick, Shiying Zhong, Jinnan Li, Chloe Walker, Lewis Harrison, James Jackson, Sophie Barlow, Sarah Cotton   +8 more
doaj   +1 more source

Physician- and patient-reported perspectives on myasthenia gravis in Europe: a real-world survey

Orphanet Journal of Rare Diseases, 2023
Background Myasthenia gravis (MG) is a rare, chronic, debilitating, unpredictable, and potentially life-threatening neuromuscular disease. There is a lack of real-world data on disease management that could be used to further understand and address unmet
Milada Mahic, Ali Bozorg, Jonathan DeCourcy, Keisha Golden, Gregor Gibson, Christian Taylor, Anna Scowcroft   +6 more
doaj   +1 more source

Real-world assessment of the impact of “OFF” episodes on health-related quality of life among patients with Parkinson’s disease in the United States

BMC Neurology, 2021
Background Many patients with Parkinson’s disease (PD) who receive carbidopa/levodopa experience symptom reemergence or worsening, or “OFF” episodes.
Andrew Thach, Eddie Jones, Eric Pappert, James Pike, Jack Wright, Alexander Gillespie   +5 more
doaj   +1 more source

Benefit of prompt initiation of single-inhaler fluticasone furoate, umeclidinium, and vilanterol (FF/UMEC/VI) in patients with COPD in England following an exacerbation: a retrospective cohort study

Respiratory Research, 2023
Background Triple therapy is recommended for patients with chronic obstructive pulmonary disease (COPD) who remain symptomatic despite dual therapy. The optimal timing of triple therapy following an exacerbation of COPD is unknown. The outcomes of prompt
Afisi S. Ismaila, Kieran J. Rothnie, Robert P. Wood, Victoria L. Banks, Lucinda J. Camidge, Alexandrosz Czira, Chris Compton, Raj Sharma, Shannon N. Millard, Olivia Massey, David M. G. Halpin   +10 more
doaj   +1 more source

Machine learning using longitudinal prescription and medical claims for the detection of non-alcoholic steatohepatitis (NASH)

BMJ Health & Care Informatics, 2022
Objectives To develop and evaluate machine learning models to detect patients with suspected undiagnosed non-alcoholic steatohepatitis (NASH) for diagnostic screening and clinical management.Methods In this retrospective observational non-interventional ...
Orla Doyle, Ozge Yasar, Patrick Long, Brett Harder, Hanna Marshall, Sanjay Bhasin, Suyin Lee, Mark Delegge, Stephanie Roy, Nadea Leavitt, John Rigg   +10 more
doaj   +1 more source

Impact of next-generation hormonal agents on treatment patterns among patients with metastatic hormone-sensitive prostate cancer: a real-world study from the United States, five European countries and Japan

BMC Urology, 2022
Background Until five years ago, the metastatic hormone-sensitive prostate cancer (mHSPC) treatment landscape was dominated by the use of androgen deprivation therapy (ADT) alone.
Andrea Leith, Amanda Ribbands, Jeri Kim, Emily Clayton, Liane Gillespie-Akar, Lingfeng Yang, Sameer R. Ghate   +6 more
doaj   +1 more source

Cross-walk of the Chronic Liver Disease Questionnaire for Nonalcoholic Steatohepatitis (CLDQ-NASH) and the EuroQol EQ-5D-5L in patients with NASH

Health and Quality of Life Outcomes, 2023
Background Nonalcoholic steatohepatitis (NASH) is a chronic progression of nonalcoholic fatty liver disease, which can negatively impact the health-related quality of life (HRQoL) of affected individuals. HRQoL in NASH has been assessed using the disease-
Jesse Fishman, Victoria Higgins, James Piercy, James Pike   +3 more
doaj   +1 more source

Unmet needs in uncomplicated urinary tract infection in the United States and Germany: a physician survey

BMC Infectious Diseases, 2023
Background Uncomplicated urinary tract infections (uUTIs/acute cystitis) are among the most common infections in women worldwide. There are differences in uUTI treatment guidelines between countries and understanding the needs of physicians in diverse ...
Megan O’Brien, Alen Marijam, Fanny S. Mitrani-Gold, Laura Terry, Gavin Taylor-Stokes, Ashish V. Joshi   +5 more
doaj   +1 more source

COVID-19 impact on the decision process of the Italian Medicine Agency: a quantitative assessment

Global & Regional Health Technology Assessment, 2023
Background: Since the COVID-19 pandemic has placed more attention on drugs’ approval process and the importance of rapid decision-making in the healthcare sector, it is crucial to assess how time to market (TTM) of drugs varied.
Beatrice Canali, Laura Candelora, Francesca Fiorentino, Tom Halmos, Paola La Malfa, Francesca Massara, Chiara Vassallo, Duccio Urbinati   +7 more
doaj   +1 more source

Feasibility of Using Oncology-Specific Electronic Health Record (EHR) Data to Emulate Clinical Trial Eligibility Criteria

Pharmacoepidemiology, 2023
We examined eligibility criteria from recent oncology clinical trials to see whether real-world data (RWD) from electronic health records (EHRs) could be used to create external control groups for clinical trials.
Thomas W. Wilson, Joseph T. Dye, Sarah Spark, Nicholas J. Robert, Janet L. Espirito, E. Susan Amirian   +5 more
doaj   +1 more source