Results 161 to 170 of about 1,529,109 (298)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Real-world evidence of measurable residual disease assessment in multiple myeloma. [PDF]
Blood AdvCedena MT +21 more
europepmc +1 more source
XPath Satisfiability with Parent Axes or Qualifiers Is Tractable under Many of Real-World DTDs [PDF]
, 2013 Yasunori Ishihara +4 more
openalex +1 more source
Real-World Solutions for Real-World Collaboration Problems
, 2003 Are you finding collaboration with faculty difficult to initiate? How about a new approach? Problem-based learning (PBL) is an instruction method that investigates and resolves messy, real-world dilemmas. This workshop demonstrates how librarians at Purdue University worked with faculty to incorporate information literacy skills into course content ...
Macklin, Alexius Smith, Fosmire, Michael
openaire +1 more source