Results 231 to 240 of about 23,126,500 (355)

Defining Age to Screen and Real-World Effectiveness for Early-Onset Colorectal Cancer. [PDF]

Cancer Sci
Wang L, Qiu Y, Chen X, Wu W, Zhu C, Chen W, Pan T, Hang D, Du L.   +8 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Light exposure and sleep architecture in real-world settings. [PDF]

NPJ Biol Timing Sleep
Akgun SG, Gemici B, Roddis C, Bickerstaff L, Otalora BB, Milosavljevic N, Brown TM, Lucas RJ, Didikoglu A.   +8 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Difficult-To-Manage Axial Spondyloarthritis: Bridging Consensus Definitions and Real-World Practice. [PDF]

Int J Rheum Dis
Hsu TC, Wei JC.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Real-world solutions for real-world settings: Effects of storage conditions on Streptococcus pneumoniae detection

Wee-Hee A, Pell C, Ortika B, Nation ML, Russell F, von Mollendorf C, Mungun T, Tundev O, Tran HP, Nguyen TV, Temple B, Mulholland EK, Hassan AI, Ibrahim SA, Flasche S, Zandvoort Kv, Checchi F, Nikolaou E, Satzke C.   +18 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Durvalumab-Tremelimumab in Advanced Hepatocellular Carcinoma: Real-World Data From the LOR-HCC (Lombardy Real-World HCC Group). [PDF]

Liver Int
Casadei-Gardini A, Canova L, Tosi F, Camera S, Bocchero E, Pozzoni P, Torchio M, Corallo S, Costantino D, Stagno A, Grizzi G, Gengarle R, Tomasello G, Ansarin N, Bruccoleri M, Bencardino K, Persano M, Pino M, Riva A, Vavassori S, Argiento L, Mazzarelli C, De Giorgio M, Caremoli ER, Rimini M, Pressiani T, Rimassa L, Iavarone M.   +27 more
europepmc   +1 more source