Results 261 to 270 of about 23,126,500 (355)

Real-world use of maralixibat in biliary atresia: a case series. [PDF]

Front Pediatr
Dilwali N, Mogul DB, Vandriel SM, Tokman T, Chapin CA, Roquelaure B, Rousseva R, Ferreira J, Martinez M, Kohlmaier B.   +9 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

AI-ECG Risk Stratification for Atrial Fibrillation: Real-World Performance and Explainability. [PDF]

JACC Adv
Matsuo K, Sobue Y, Miyake T, Takeda K, Watanabe E, Matsuo H, Izawa H.   +6 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Immune checkpoint inhibitor treatment - real-world use and outcomes in Sweden 2015-2023. [PDF]

Ups J Med Sci
Illergard K, Soto P, Arpegård J, Schiza A, Pahnke S.   +4 more
europepmc   +1 more source

Elranatamab in Relapsed/Refractory Multiple Myeloma: A Multicenter Real-World Study from Türkiye. [PDF]

J Clin Med
Bozdemir A, Hacıoğlu S, Akgün Çağlıyan G, Alayvaz Aslan N, Uzun SU, Kara K, Iltar U, Yücel OK, Ataş Ü, Arslan Kirezli S, Gemici Aİ, Alacacıoğlu İ, Yeniay MK, Bilgir O, Narlı Özdemir Z, Haydaroğlu Şahin H, Uysal A, Aksöz Z, Güven ZT, Aygün K, Tekinalp A, Yılmaz M, Atmaca Mutlu C, Pektaş G, Salim O, Güler N.   +25 more
europepmc   +1 more source