Results 231 to 240 of about 2,242,374 (316)

In Defence of Context: Surrogates, Sequencing, and Real-world Evidence in Genitourinary Oncology. [PDF]

Eur Urol Open Sci
Roviello G, Mancini S, Santoni M.
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Real-World Evidence in Drug Approvals at the European Medicines Agency.

JAMA Netw Open
Bachinger M, Jankowski MA, Kesselheim AS, Krüger N.   +3 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Real World Evidence Versus Randomised Controlled Trials: Is the Future of Nutritional Sciences Research in Electronic Health Records? [PDF]

Nutr Bull
Dalrymple KV.
europepmc   +1 more source

Editorial: Real-world data and real-world evidence in lung cancer

Frontiers in Oncology
Valerio Gristina, Chukwuka Eze
openaire   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

O1 Impact of intravenous belimumab treatment on steroid use and disease activity in patients with Systemic Lupus Erythematosus (SLE) in the US in clinical practice: 24-month results from the OBSErve study

Lupus Science and Medicine
Robert Wood, Roger A Levy, Rosie Wild, Elke Rottier, Holly A Quasny, Marguerite Bracher, Seth Anderson, Daniel Moldaver, Alexandra Cusmano   +8 more
doaj   +1 more source

Investigating CAR-T Treatment Access for Multiple Myeloma Patients Using Real-World Evidence. [PDF]

Cancers (Basel)
Davidson J, Kumar A, Patel A, Chen IY, Butte AJ, Zack T.   +5 more
europepmc   +1 more source