Results 121 to 130 of about 17,110,106 (300)
La República de los psicoanalistas
Desde el Jardín de Freud, 2012 En la comunidad analítica se ha trabajado la función del síntoma en la construcción del lazo social. El tema central del presente artículo pretende abrir la reflexión en torno al aporte de Lacan en los últimos años de su enseñanza, con respecto a la ...
Ramón Menéndez Pla
doaj
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
La segregación del psicoanalista
Desde el Jardín de Freud, 2013 Tomando como punto de partida las observaciones lacanianas sobre la segregación en su “Discurso de clausura de las jornadas sobre psicosis infantil”, este artículo se propone elucidar en qué forma Lacan introduce la cuestión; si la segregación es una ...
Marie-Jean Sauret
doaj
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Lo que la erótica y la poética enseñan al psicoanálisis en relación a la verdad
Desde el Jardín de Freud, 2016 El analista, a la hora de pensar el estatuto de la verdad en psicoanálisis, encuentra que existen dos vías férreas donde, no sin pasar por la verdad, se puede cernir ese real que es el corazón de la práctica analítica.
Matías Laje +2 more
doaj
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
The Journal of Studies in Language, Culture and SocietyUsing the figure of the sardine, the article explores the issues at stake in contemporary art and the digital world, the internet, in relation to current post-colonial situations and contexts.
Simone Hélène Sirven
doaj