Results 51 to 60 of about 11,132,088 (256)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Light-gated integrator for highlighting kinase activity in living cells

Nature Communications
Protein kinases are key signaling nodes that regulate fundamental biological and disease processes. Illuminating kinase signaling from multiple angles can provide deeper insights into disease mechanisms and improve therapeutic targeting.
Wei Lin, Abhishek Phatarphekar, Yanghao Zhong, Longwei Liu, Hyung-Bae Kwon, William H. Gerwick, Yingxiao Wang, Sohum Mehta, Jin Zhang   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Towards Manipulation of Unknown Objects [PDF]

, 2012
Li Q, Haschke R, Ritter H, Bolder B. Towards Manipulation of Unknown Objects. Presented at the 10th International IFAC Symposium on Robot Control, Dubrovnik, Croatia.We propose a simple but efficient control strategy to manipulate objects of unknown ...
Bolder, Bram, Ritter, Helge ; https://orcid.org/, Haschke, Robert ; https://orcid.org/, Li, Qiang ; https://orcid.org/   +3 more
core  

All-optical interrogation of brain-wide activity in freely swimming larval zebrafish

iScience
Summary: We introduce an all-optical technique that enables volumetric imaging of brain-wide calcium activity and targeted optogenetic stimulation of specific brain regions in unrestrained larval zebrafish. The system consists of three main components: a
Yuming Chai, Kexin Qi, Yubin Wu, Daguang Li, Guodong Tan, Yuqi Guo, Jun Chu, Yu Mu, Chen Shen, Quan Wen   +9 more
doaj   +1 more source

Pengaruh Manipulasi Aktivitas Riil terhadap Dividen Perusahaan LQ 45 di Bursa Efek Indonesia

Sorot, 2016
Penelitian ini menguji Pengaruh manipulasi aktivitas riil terhadap dividen perusahaan LQ 45 di Bursa Efek Indonesia. Untuk menyelidiki masalah ini, studi ini menggunakan data-data dari Bursa Efek Indonesia.
Eka Hariyani
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Framework for Experimenting Co-creation in Real-Life Contexts

, 2021
The chapter describes the methodology applied throughout the experimentation, the application of co-design, the tools used and their role briefly illustrating the single cases.
Marion Real, Felicitas Schmittinger, Schmittinger, Felicitas, Real, Marion   +3 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source