Results 71 to 80 of about 11,132,088 (256)

An exo-cell assay for examining real-time γ-secretase activity and inhibition

Molecular Neurodegeneration, 2009
γ-Secretase is an aspartyl protease that cleaves multiple substrates that are involved in broad biological processes ranging from stem cell development to neurodegeneration.
Tian Yuan, Shelton Christopher C, Frattini Mark G, Li Yue-Ming   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Rotary Surface Object Manipulation by Multifingered Robot Hand [PDF]

, 2012
Li Q, Haschke R, Ritter H, Bolder B. Rotary Surface Object Manipulation by Multifingered Robot Hand. Presented at the 7th German Conference on Robotics, Munich, Germany.We propose a simple but efficient control strategy to manipulate objects of unknown ...
Bolder, Bram, Ritter, Helge ; https://orcid.org/, Haschke, Robert ; https://orcid.org/, Li, Qiang ; https://orcid.org/   +3 more
core  

The impact of board gender diversity on the accrual/real earnings management practice: evidence from an emerging market

Future Business Journal
This paper examines the impact of gender diversity on financial reporting quality (accrual and real earnings management). We use a sample of 78 Egyptian listed companies over the period 2009–2021.
Eman F. Attia, Sameh Yassen, Ahmed Chafai, Ahmed Qotb   +3 more
doaj   +1 more source

Enterprise risk management and earnings management under financial distress: evidence from an emerging market

Cogent Business & Management
This study examines how financial distress influences earnings management through accrual-based and real activity-based channels and investigates the moderating role of enterprise risk management (ERM) in an emerging market setting.
Thuy Anh Nguyen
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia

Nature Communications
Caspases are known to mediate neuronal apoptosis during brain development. However, here we show that nonapoptotic activation of caspase-3 at presynapses drives microglial synaptic phagocytosis.
Megumi Andoh, Natsuki Shinoda, Yusuke Taira, Tasuku Araki, Yuka Kasahara, Haruki Takeuchi, Masayuki Miura, Yuji Ikegaya, Ryuta Koyama   +8 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

How board structure affects accrual and real earnings management in Ethiopia

Discover Sustainability
This study investigates the effect of board structure on accrual and real earnings management in Ethiopia. Before the enactment of Proclamation No. 1248/2021 and the subsequent official market launch in 2025, Ethiopia’s capital market operated under ...
Muhammed Yismaw, Arega Seyoum, Abebe Menberu   +2 more
doaj   +1 more source

Dividend Policy and the Trade-Off Between Real and Accrual-Based Earnings Management: Empirical Evidence from the KOSPI Market

International Journal of Financial Studies
In this study, we examine whether dividend policy is associated differently with accrual-based earnings management and real earnings management measured through abnormal operating cash flow.
Okechukwu Enyeribe Njoku, Seonhye Jeong, Ana Belén Tulcanaza-Prieto, Hong Geun Yoon, Younghwan Lee   +4 more
doaj   +1 more source