Results 21 to 30 of about 424,638 (200)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

J-factors of short DNA molecules

, 2016
The propensity of short DNA sequences to convert to the circular form is studied by a mesoscopic Hamiltonian method which incorporates both the bending of the molecule axis and the intrinsic twist of the DNA strands.
Bates A. D., Feynman R. P., Feynman R. P., Marco Zoli, Schulman L. S.   +4 more
core   +1 more source

NMR multiple quantum coherences in quasi-one-dimensional spin systems: Comparison with ideal spin-chain dynamics [PDF]

, 2009
The 19F spins in a crystal of fluorapatite have often been used to experimentally approximate a one-dimensional spin system. Under suitable multi-pulse control, the nuclear spin dynamics may be modeled to first approximation by a double-quantum one ...
Brian Pepper, C. P. Slichter, Chandrasekhar Ramanathan, D. Stauffer, David G. Cory, F. H. L. Essler, Lorenza Viola, M. A. Nielsen, N. Leroy, Natania Antler, Paola Cappellaro, R. Kubo, S. I. Doronin, U. Haeberlen, Viatcheslav V. Dobrovitski, Wenxian Zhang   +15 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Genuine quantum correlations in quantum many-body systems: a review of recent progress

, 2018
Quantum information theory has considerably helped in the understanding of quantum many-body systems. The role of quantum correlations and in particular, bipartite entanglement, has become crucial to characterise, classify and simulate quantum many body ...
De Chiara, Gabriele, Sanpera, Anna
core   +1 more source

Bounded Satisfiability for PCTL [PDF]

, 2012
While model checking PCTL for Markov chains is decidable in polynomial-time, the decidability of PCTL satisfiability, as well as its finite model property, are long standing open problems.
Bertrand, Nathalie, Fearnley, John, Schewe, Sven   +2 more
core   +5 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Growth, microstructure, and failure of crazes in glassy polymers

, 2003
We report on an extensive study of craze formation in glassy polymers. Molecular dynamics simulations of a coarse-grained bead-spring model were employed to investigate the molecular level processes during craze nucleation, widening, and breakdown for a ...
A.R.C. Baljon, A.R.C. Baljon, A.S. Argon, A.S. Argon, B.D. Lauterwasser, C. Creton, E. Paredes, E.J. Kramer, E.J. Kramer, G.H. Michler, G.J. Salomons, G.J. Salomons, H.R. Brown, H.R. Brown, H.R. Brown, H.R. Brown, J. Rottler, J. Rottler, J. Rottler, J. Washiyama, Jörg Rottler, K. Kremer, L.J. Fetters, M. Pütz, M.J. Stevens, M.J. Stevens, Mark O. Robbins, R. Faller, R. Faller, R. Quinson, R. Raghava, R.S. Kody, S.W. Sides, S.W. Sides, T.N. Krupenkin, T.N. Krupenkin   +35 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Thermal conduction in classical low-dimensional lattices

, 2003
Deriving macroscopic phenomenological laws of irreversible thermodynamics from simple microscopic models is one of the tasks of non-equilibrium statistical mechanics.
Lepri, Stefano, Livi, Roberto, Politi, Antonio   +2 more
core   +1 more source