Results 31 to 40 of about 424,638 (200)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Monte Carlo simulations of interfaces in polymer blends

, 1998
We review recent simulation studies of interfaces between immiscible homopolymer phases. Special emphasis is given to the presentation of efficient simulation techniques and powerful methods of data analysis, such as the analysis of capillary wave ...
Mueller, M., Schmid, F.
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Topological effects in ring polymers: A computer simulation study

, 1998
Unconcatenated, unknotted polymer rings in the melt are subject to strong interactions with neighboring chains due to the presence of topological constraints. We study this by computer simulation using the bond-fluctuation algorithm for chains with up to
A. Kolinski, A. Kolinski, A. Kolinski, A. Kolinski, C. R. Bartels, D. Gersappe, D. Richter, E. F. Casassa, G. B. McKenna, G. B. McKenna, G. Hadziioannou, H.-P. Deutsch, H.L. Frisch, I. Carmesin, J. D. Ferry, J. des Cloizeaux, J. Klein, J. Klein, J. P. Wittmer, J. Reiter, J. Roovers, J. Roovers, J. Roovers, J. S. Shaffer, J. Wittmer, K. Dogson, K. S. Schweizer, K. S. Schweizer, K. S. Schweizer, M. Antonietti, M. Doi, M. E. Cates, M. E. Fisher, M. G. Brereton, M. Müller, M.E. Cates, P. J. Mills, S. F. Tead, S. Geyler, T. P. Lodge, T. Pakula, T. Pakula, T. Pakula, W. Burchard, W. Paul, W. Paul   +45 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Measuring D_A and H at z=0.35 from the SDSS DR7 LRGs using baryon acoustic oscillations

, 2013
We present measurements of the angular diameter distance D_A(z) and the Hubble parameter H(z) at z=0.35 using the anisotropy of the baryon acoustic oscillation (BAO) signal measured in the galaxy clustering distribution of the Sloan Digital Sky Survey ...
Abazajian, Abdalla, Albrecht, Alcock, Amendola, Anderson, Angulo, Angulo, Antonio J. Cuesta, Beutler, Blake, Blake, Blake, Bond, Cameron K. McBride, Carroll, Chuang, Chuang, Cole, Conley, Crocce, Daniel J. Eisenstein, Dolney, Eisenstein, Eisenstein, Eisenstein, Eisenstein, Eisenstein, Eisenstein, Eisenstein, Feldman, Fisher, Fukugita, Gaztañaga, Glazebrook, Gunn, Gunn, Guzik, Hamilton, Hoffman, Hogg, Holtzman, Hu, Hu, Hu, Huff, Hütsi, Ivezić, Jarosik, Jeong, Kaiser, Kazin, Kazin, Kazin, Komatsu, Landy, Larson, Lewis, Linder, Linder, Ma, Matsubara, Mehta, Mehta, Meiksin, Nikhil Padmanabhan, Noh, Nusser, Okumura, Padmanabhan, Padmanabhan, Padmanabhan, Padmanabhan, Padmanabhan, Park, Peebles, Percival, Percival, Perlmutter, Pier, Reid, Riess, Sanchez, Seo, Seo, Seo, Seo, Seo, Smith, Smith, Strauss, Sunyaev, Takahashi, Taruya, Tegmark, Tucker, Xiaoying Xu, Xu, York, Zaroubi   +99 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Criticality and entanglement in random quantum systems

, 2009
We review studies of entanglement entropy in systems with quenched randomness, concentrating on universal behavior at strongly random quantum critical points.
Moore, Joel E., Refael, Gil
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Measurements of Secondary Cosmic Microwave Background Anisotropies with the South Pole Telescope

, 2009
We report cosmic microwave background (CMB) power spectrum measurements from the first 100 sq. deg. field observed by the South Pole Telescope (SPT) at 150 and 220 GHz.
A. A. Stark, A. T. Crites, A. T. Lee, B. A. Benson, B. Stalder, Bai, Bode, Bond, Brown, C. L. Chang, C. L. Reichardt, C. Pryke, Carlstrom, Dawson, Duffy, Dunkley, E. M. George, E. M. Leitch, E. Shirokoff, Finkbeiner, Friedman, G. P. Holder, Górski, H. G. Spieler, H.-M. Cho, Haiman, Hall, Hinshaw, Hivon, J. D. Hrubes, J. D. Vieira, J. E. Carlstrom, J. E. Ruhl, J. J. McMahon, J. J. Mohr, J. Mehl, Jones, K. A. Aird, K. K. Schaffer, K. Vanderlinde, Knox, Knox, Komatsu, Komatsu, Kravtsov, L. E. Bleem, L. Knox, L. Shaw, Lagache, Lewis, Lin, M. A. Dobbs, M. Joy, M. Lueker, Mason, N. R. Hall, N. W. Halverson, Nolta, O. Zahn, P. A. R. Ade, Pascale, Polenta, R. Keisler, R. Williamson, Reichardt, Reichardt, S. Padin, S. S. Meyer, Sayers, Sehgal, Sharp, Shaw, Sievers, Staniszewski, Sunyaev, Sunyaev, T. de Haan, T. E. Montroy, T. M. Crawford, T. Plagge, Vieira, Viero, W. L. Holzapfel, Z. Staniszewski, Zahn   +84 more
core   +1 more source