Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Real Options under Choquet-Brownian Ambiguity [PDF]
Real options models characterized by the presence of ambiguity have been recently proposed. But based on recursive multiple-priors approaches to solve ambiguity, these seminal models reduce individual preferences to extreme pessimism by considering only ...
André Lapied +2 more
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ESG-Driven Investment Decisions in Photovoltaic Projects
EnergiesAs global climate change intensifies and environmental awareness increases, investing in renewable energy has become a primary economic and social development priority.
Ruolan Wei +3 more
doaj +1 more source
Valuing Indoor Air Quality Benefits in a Healthcare Construction Project with Real Option Analysis
Buildings, 2014 Indoor air quality (IAQ) can produce significant economic benefits for the tenant during the use of the building. However, currently the potential economic benefits on a tenant’s employees’ health and performance are not considered in feasibility studies
Juho-Kusti Kajander +2 more
doaj +1 more source
Valuation of a Company Producing and Trading Seaweed for Human Consumption: Classical Methods vs. Real Options. [PDF]
Int J Environ Res Public Health, 2021 Pérez-Vas R +2 more
europepmc +1 more source
Acquisitions and Real Options: The Greenfield Alternative
Journal of Management Studies, 2010 abstract Although acquisitions are a popular way to enter new markets, empirical evidence tends to indicate few benefits accrue to acquiring firms. This might be the case because firms use acquisitions when they should be employing an alternative mode of expansion. Applying real options theory to this issue, we suggest that greenfield start‐up ventures
Brouthers, Keith D., Dikova, D.
openaire +4 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Investing in climate change adaptation and mitigation: A methodological review of real-options studies. [PDF]
Ambio, 2021 Ginbo T, Di Corato L, Hoffmann R.
europepmc +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Application of the American Real Flexible Switch Options Methodology A Generalized Approach [PDF]
The paper deals with the inclusion of flexibility in financial decision-making under risk. It describes the application of the real options methodology with the possibility of sequential multinomial decision-making. The basic intention is to describe and
Zdenìk Zmeškal
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