Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Recent Advances in Real Options Signaling Games
Financial economics have benefited from game theory advances and its application to various domains where competition is present. Following relevant research this paper presents a literature review of recent works on the intersection of real options and ...
George Rigopoulos
doaj +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
USING OF REAL OPTIONS IN PROJECT FINANCING WITH LEASED ASSETS
In the conditions of the growing competition and growth of number of ahead of schedule terminated leasing transactions lessors need to predict correctly the probable financial risks connected with uncertain behavior of all participants of the project ...
N. I. Nesterova
doaj
Correction to: Investing in climate change adaptation and mitigation: A methodological review of real-options studies. [PDF]
Ginbo T, Di Corato L, Hoffmann R.
europepmc +1 more source
Investment Decision in a Broadband Internet Network: A Real Options Approach [PDF]
This article is a case study analysing the decision of a telecommunications operator to roll out ADSL infrastructures in areas of low population density.
Charlotte KRYCHOWSKI
core
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Subsidy policy selection of elderly care service projects under uncertain actual demand: a real options analysis based on China's experience. [PDF]
Song H, Ji K, Sun T.
europepmc +1 more source
Monte Carlo Estimation of Project Volatility for Real Options Analysis [PDF]
Volatility is a fundamental parameter for option valuation. In particular, real options models require project volatility, which is very hard to estimate accurately because there is usually no historical data for the underlying asset.
Pedro Godinho
core
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source

