Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Monte Carlo Estimation of Project Volatility for Real Options Analysis [PDF]
Volatility is a fundamental parameter for option valuation. In particular, real options models require project volatility, which is very hard to estimate accurately because there is usually no historical data for the underlying asset.
Pedro Godinho
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Investment Decision in a Broadband Internet Network: A Real Options Approach [PDF]
This article is a case study analysing the decision of a telecommunications operator to roll out ADSL infrastructures in areas of low population density.
Charlotte KRYCHOWSKI
core
USING OF REAL OPTIONS IN PROJECT FINANCING WITH LEASED ASSETS
Финансы: теория и практика, 2017 In the conditions of the growing competition and growth of number of ahead of schedule terminated leasing transactions lessors need to predict correctly the probable financial risks connected with uncertain behavior of all participants of the project ...
N. I. Nesterova
doaj
Correction to: Investing in climate change adaptation and mitigation: A methodological review of real-options studies. [PDF]
Ambio, 2022 Ginbo T, Di Corato L, Hoffmann R.
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Reacting to Risk with Real Options: Valuation of Managerial Flexibility in IT Projects. [PDF]
Since flexibility is a critical success factor in relation to the management and design of IT investments, and understanding flexibility is a difficult issue, it is important to explore how firms build flexibility into their IT investment decisions. This
Hilhorst, C.A.R.
core
Nuclear Fuel Cycle Evaluation and Real Options
Acta Polytechnica, 2008 The first part of this paper describes the nuclear fuel cycle. It is divided into three parts. The first part, called Front-End, covers all activities connected with fuel procurement and fabrication.
L. Havlíček
doaj
Subsidy policy selection of elderly care service projects under uncertain actual demand: a real options analysis based on China's experience. [PDF]
BMC Geriatr, 2022 Song H, Ji K, Sun T.
europepmc +1 more source