Results 121 to 130 of about 2,310,364 (380)

Real Options Theory for Law Makers [PDF]

open access: yes
The formulation of legal rules is a challenging issue for lawmakers. Trade-offs are inevitable between providing more guidance by specific rules and enlarging the scope by general rules.
Bruno Deffains, Marie Obidzinski
core  

Vertical inhibition of p110α/AKT and N‐cadherin enhances treatment efficacy in PIK3CA‐aberrated ovarian cancer cells

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1132-1154, April 2025.
PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang   +6 more
wiley   +1 more source

Real Islamic Logic [PDF]

open access: yesarXiv, 2011
Four options for assigning a meaning to Islamic Logic are surveyed including a new proposal for an option named "Real Islamic Logic" (RIL). That approach to Islamic Logic should serve modern Islamic objectives in a way comparable to the functionality of Islamic Finance.
arxiv  

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

open access: yesMolecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam   +2 more
wiley   +1 more source

Caracterización y análisis de modelos de evaluación económica de proyectos de inversión bajo incertidumbre

open access: yesIngenieria Industrial, 2009
Este articulo presenta los métodos  actualmente disponibles para la evaluación de proyectos, dejando de manifiesto las falencias de los métodos tradicionales como el Método de Flujos de Caja Descontados, cuando son usados para evaluar proyectos con alta ...
Feliciano Alejandro Garcia Ruiz   +1 more
doaj  

Real Options and Threshold Strategies [PDF]

open access: yesarXiv, 2015
The paper considers an investment timing problem appearing in real options theory. Present values from an investment project are modeled by general diffusion process. We prove necessary and sufficient conditions under which an optimal investment time is induced by threshold strategy.
arxiv  

The Real Options Attached to an Investment Project [PDF]

open access: yes
The real options capture the importance of the managerial team’s role in creating value through investment projects. The investments in real assets have a set of options that managers can exercise during the period of the project to increase the value of
Mihai-Cristian DINICA
core  

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

open access: yesMolecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou   +13 more
wiley   +1 more source

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