Results 121 to 130 of about 6,847,415 (304)
Ingenieria Industrial, 2009 Este articulo presenta los métodos actualmente disponibles para la evaluación de proyectos, dejando de manifiesto las falencias de los métodos tradicionales como el Método de Flujos de Caja Descontados, cuando son usados para evaluar proyectos con alta ...
Feliciano Alejandro Garcia Ruiz +1 more
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Notes on Applying Real Options to Climate Change Adaptation Measures, with examples from Vietnam [PDF]
A factor common to all adaptation measures is the uncertainty that is the hallmark of climate change. The timing, intensity and location of climate change impacts is not known to any degree of precision.
Dobes, Leo
core
Urban ScienceNowadays, the urban population is steadily increasing worldwide and, as a result, global construction output is expected to grow to more than 16 trillion EUR by 2030.
Dimitrios Kantianis +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
A Real-World Way to Manage Real Options
, 2004 Each corporate growth project is an option, in the sense that managers face choices--push ahead or pull back--along the way. Yet many companies hesitate to apply options theory to initiatives such as R&D; and geographic expansion, partly because these ...
Copeland, Tom, Tufano, Peter
core
Análise de opções reais aplicada na diversificação da produção rural no estado do Paraná
Revista de Economia e Sociologia RuralResumo O presente artigo tem o objetivo de analisar a contribuição do uso da Teoria das Opções Reais (TOR) na análise de investimentos da diversificação da produção rural no estado do Paraná.
Wagner Dantas Souza Junior +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Advanced Biofuel Production in Louisiana Sugar Mills: an Application of Real Options Analysis [PDF]
In order to more fully study the risks and uncertainty involved in cellulosic ethanol production, we examine a simulated plant in South Louisiana using Real Options Analysisreal options, risk, uncertainty, cellulosic ethanol, energy cane, sorghum ...
Salassi, Michael E. +3 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source