Results 141 to 150 of about 3,743,885 (328)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Using Real Options Analysis for Evaluating Uncertain Investments in Information Technology: Insights from the ICIS 2001 Debate

, 2002
Paul P. Tallon, Robert J. Kauffman, Henry C. Lucas, Andrew B. Whinston, Kevin Zhu   +4 more
openalex   +2 more sources

Real options analysis in the engineering company practice [PDF]

, 2013
Václav Klepáč, Petr Kříž, David Hampel   +2 more
openalex   +1 more source

End of life decommissioning and recycling of solar panels in the United States. A real options analysis [PDF]

, 2020
C. Echevarría Ruiz de Vargas, Marc Chesney   +1 more
openalex   +1 more source

When to wait for more evidence? Real options analysis in proton therapy. [PDF]

Oncologist, 2011
Grutters JP, Abrams KR, de Ruysscher D, Pijls-Johannesma M, Peters HJ, Beutner E, Lambin P, Joore MA.   +7 more
europepmc   +1 more source

None of the Above, Less of the Right: Parallel Patterns between Humans and LLMs on Multi-Choice Questions Answering [PDF]

arXiv
Multiple-choice exam questions with "None of the above" (NA) options have been extensively studied in educational testing, in which existing research suggests that they better assess true knowledge. However, their impact on Large Language Models (LLMs) evaluation remains underexplored.
arxiv  

Building Real Options into Physical Systems with Stochastic Mixed-Integer Programming [PDF]

, 2005
The problem of building real options into physical systems has three features: real options are not as easily defined as financial options; path-dependency and interdependencies among projects mean that the standard tools of options analysis tools are ...
de Neufville, Richard, Wang, Tao
core  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Evaluating a portfolio of projects through the real options analysis [PDF]

, 2020
Aleksandr B. Lanchakov, Sergei A. Filin, A. Zh. Yakushev   +2 more
openalex   +1 more source