Results 161 to 170 of about 666,196 (263)

Impact of Selumetinib on Long-Term Pain Medication Utilization in Pediatric Patients: A Retrospective US Claims Database Study. [PDF]

Pain Ther
Lyons G, Dettling T, Bowling A, Anand A, Sicilia M, van der Pluijm W, Guikema B, Meade J.   +7 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Integrating Drug Repurposing into EU Health Crisis Preparedness: The Strategic Role of Health Emergency Preparedness and Response Authority (HERA). [PDF]

Pharmacy (Basel)
Toshev A, Gueorguiev S, Mihaylova A, Getova-Kolarova V, Madzharov V, Mirchev D, Petkova-Gueorguieva E.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Increased treatment options and improved survival in real-world patients with HER2-positive advanced gastric cancer from 2011 to 2023. [PDF]

Ther Adv Gastroenterol
Shimozaki K, Ooki A, Yoshikawa K, Yoshino K, Udagawa S, Osumi H, Fukuoka S, Wakatsuki T, Ogura M, Takahari D, Shinozaki E, Chin K, Yamaguchi K.   +12 more
europepmc   +1 more source

Fuzzy Valuation in Real Options Analysis

Proceedings of the Fuzzy System Symposium, 2009
Zhang, Hui Ming, Lin, Pei-Chun, Wu, Berlin, Watada, Junzo   +3 more
openaire   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

How continuous is continuous enough? Comparing the reliability of continuous and discrete scales. [PDF]

Behav Res Methods
Yang WH, Sung YT, Chou YT.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The Performance of DeepSeek R1 and Gemini 3 in Complex Medical Scenarios: Comparative Study. [PDF]

JMIRx Med
Bajwa M, Hoyt R, Knight D, Haider M.
europepmc   +1 more source