Results 141 to 150 of about 29,012,891 (356)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

An Investment Criterion Incorporating Real Options [PDF]

Investment in infrastructure such as the information and communication technology sector requires large, substantial amounts, most of which are sunk or irreversible.
Paul RAPPOPORT, Hirofumi SUTO, James ALLEMAN   +2 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

INCORPORATING RISK PREFERENCES INTO REAL OPTIONS MODELS [PDF]

This paper develops a framework to link the expected utility analysis to real options models in order to capture the joint effects of risk aversion and irreversibility associated with real investments.
Isik, Murat
core  

Contribution to risk assessment in agricultural projects: conjunction of Monte-Carlo and Black-Scholes methods

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2018
This article treats the way risk is integrated in financial and economic projects analysis, especially agricultural ones. Its objective is not to study the profitability or the risk of a particular project, but it proposes an idea that relates to the ...
Mohamed Taha LAHRECH, Majid BENABDELLAH
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

USING REAL OPTIONS TO EVALUATE PRODUCER INVESTMENT IN NEW GENERATION COOPERATIVES [PDF]

New Generation Cooperatives have emerged as a contemporary means for farmers to invest in further processing activities. This paper considers real options as the basis for evaluating producer investment in a start-up cooperative that involves ...
Bailey, Michael D., Sporleder, Thomas L.
core  

Enhancing Financial Decision-Making: Real Options Complementing the Net Present Value Technique in the Financial Services Sector

Journal of Management and Entrepreneurship Research
Objective: This study investigates the effectiveness of integrating real options with the Net Present Value (NPV) technique in the context of the financial services sector.
Ferina Marimuthu, Kyle Fitzgerald
doaj   +1 more source

Real options analysis in real estate investments and developments

, 2020
El análisis de proyectos inmobiliarios plantea una gran cantidad de retos. La singularidad de las características de cada uno de los tipos de inmuebles significa que una evaluación debe adaptarse cuidadosamente a cada caso. Uno de los aspectos más determinantes es la flexibilidad de gestión de los proyectos inmobiliarios.
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source