Results 161 to 170 of about 3,428,091 (391)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
OPTION VALUE OF HARVESTING: THEORY AND EVIDENCE [PDF]
Real options analysis shows that fishery harvesting becomes more conservative, and catch efficiency is raised, when exploitation is subject to irreversibility, uncertainty, and delay for a cooperative profit-maximizing fleet.
Li, Eric A.L.
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2018 This article treats the way risk is integrated in financial and economic projects analysis, especially agricultural ones. Its objective is not to study the profitability or the risk of a particular project, but it proposes an idea that relates to the ...
Mohamed Taha LAHRECH, Majid BENABDELLAH
doaj
Journal of Management and Entrepreneurship ResearchObjective: This study investigates the effectiveness of integrating real options with the Net Present Value (NPV) technique in the context of the financial services sector.
Ferina Marimuthu, Kyle Fitzgerald
doaj +1 more source
Real options for adaptive decisions in primary industries [PDF]
The long term sustainability of Australian crop and livestock farms is threatened with climate change and climate variability. In response, farmers may decide to (1) adjust practices and technologies, (2) change production systems, or (3) transform their
Greg Hertzler, Tim Capon, Todd Sanderson
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
EX-ANTE EVALUATION OF AGRI-ENVIRONMENTAL SCHEMES: COMBINING ELEMENTS OF PRIVATE AND PUBLIC DECISION MAKING [PDF]
The objective of this paper is to set a complete ex-ante evaluation to support Decision Makers in designing more efficient and effective agri-environmental contracts, through an integrated modelling of elements of private and public decision making.
Bartolini, Fabio +2 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source