Results 81 to 90 of about 4,215,956 (300)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
SLS-PLAN-IT: A knowledge-based blackboard scheduling system for Spacelab life sciences missions [PDF]
The primary scheduling tool in use during the Spacelab Life Science (SLS-1) planning phase was the operations research (OR) based, tabular form Experiment Scheduling System (ESS) developed by NASA Marshall.
Kao, Cheng-Yan, Lee, Seok-Hua
core +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
TDRSS momentum unload planning [PDF]
A knowledge-based system is described which monitors TDRSS telemetry for problems in the momentum unload procedure. The system displays TDRSS telemetry and commands in real time via X-windows.
Cross, George R. +3 more
core +1 more source
Regrasp Planning using 10,000s of Grasps
, 2017 This paper develops intelligent algorithms for robots to reorient objects. Given the initial and goal poses of an object, the proposed algorithms plan a sequence of robot poses and grasp configurations that reorient the object from its initial pose to ...
Harada, Kensuke, Wan, Weiwei
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Revista de Economia Contemporânea, 2008 Este artigo analisa a evolução dos principais fundamentos econômicos brasileiros ao longo do período de rígida administração da taxa de câmbio no Plano Real. O trabalho tem início com uma resenha acerca dos fatores que causaram as instabilidades cambiais
Fernando Antônio Ribeiro Soares +1 more
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
O cambio de equilíbrio do Brasil
Economia Aplicada, 2002 The papertriesto estimate the equilibrium real exchange rate for the Brazilian economy during the 1975-1998 period. It uses three alternative approaches in estimating the equilibrium exchange rate.
Marcos C. Holanda
doaj