Results 241 to 250 of about 20,354,300 (293)

Detection of Fungal Translocation in Patients With Alcohol Use Disorder Using a Real-Time PCR Assay. [PDF]

APMIS
Pansu N, Drakulovski P, Krasteva D, Bellet V, Lavigne JP, Dunyach-Remy C, Salipante F, Yahiaoui-Martinez A, Donnadieu-Rigole H, Bertout S.   +9 more
europepmc   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Evaluation and Clinical Validation of Pan-Specific and Clade-Specific Diagnostic Real-Time PCR Assays for Monkeypox Virus. [PDF]

J Med Virol
Chang H, Hung TH, Li B, Kong BL, Madhaven AA, Wang Y, Tsai MS, Deng D, Cui Z.   +8 more
europepmc   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Optimal Specimens and Lesions for Mpox Diagnosis Using Real-Time PCR, South Korea. [PDF]

Emerg Infect Dis
Kim DM, Muhammad M, Kim JW, Kim CM, Seo JW, Kim DY, Yun NR, Lee B, Lee M, Lee JH, Choi MM, Chung YS.   +11 more
europepmc   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

National Distribution of Bisexual and Parthenogenetic <i>Haemaphysalis longicornis</i> of Japan, and a Real-Time PCR-Based Method to Distinguish the Two Reproductive Groups. [PDF]

J Parasitol Res
Inumaru M, Noda R, Itokawa K, Matsumura R, Kimura T, Kuwata R, Nakao S, Tsuha O, Takemura A, Nishiyama S, Yamauchi T, Tamatani H, Yoshikawa A, Hattori M, Sasaki T, Watanabe M, Sawabe K, Aboshi AR, Kobayashi D, Yang C, Yamada A, Isawa H, Kasai S, Higa Y.   +23 more
europepmc   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Comparative Evaluation of Real-Time PCR, Immunochromatographic Assay, and Modified Carbapenem Inactivation Method for Carbapenemase Detection in Enterobacterales Isolates. [PDF]

Int J Mol Sci
Güner ET, Çiçek C, Bakır A, Aral M.
europepmc   +1 more source

Real-Time PCR-Based Detection of <i>Mycobacterium leprae</i> From Multiple Clinical Samples for Molecular Diagnosis of Leprosy in Côte D'Ivoire. [PDF]

J Trop Med
Dehe BR, Amon AC, Ban OV, Tiemoko GJ, Kouakou H, Bidie ADP, Dosso M, Ngazoa KS, Coulibaly ND.   +8 more
europepmc   +1 more source