Characterization and comparation of toxicity between natural realgar and artificially optimized realgar [PDF]
Frontiers in PharmacologyObjectiveRealgar possesses important medical properties. This article aims to evaluate realgar and emerging artificially optimized realgar to ensure safe clinical use.MethodsMultiple techniques were employed to test natural realgar and artificially ...
Lu Luo, Qiaochu Wang, Shuangrong Gao
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Traditional mineral medicine realgar and Realgar-Indigo naturalis formula potentially exerted therapeutic effects by altering the gut microbiota [PDF]
Frontiers in Microbiology, 2023 IntroductionRealgar has a long history ofuse in traditional medicines. However, the mechanism through which Realgar or Realgar-Indigo naturalis formula (RIF) exert therapeutic effects is only partially understood.MethodsIn this study, 60 feces and 60 ...
Qiaochu Wang, Ziwen Xu, Wang Qiaochu
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Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis [PDF]
Advanced ScienceRealgar, an arsenic‐containing traditional Chinese medicine, is commonly used in clinical practice. However, prolonged, excessive, or uncontrolled administration of Chinese patent medicines containing realgar can occasionally induce adverse effects ...
Ping Ye +7 more
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A Metabolic Profiling Study of Realgar-Induced Acute Kidney Injury in Mice
Frontiers in Pharmacology, 2021 Realgar has been used as a type of mineral drug that contains arsenic for thousands of years. Previous studies have shown that Realgar-induced acute kidney injury is associated with abnormal metabolism, but the underlying mechanism is poorly understood ...
Heng Zhou, Limin Li, Shen Ji
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Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes [PDF]
Advanced ScienceAcute promyelocytic leukemia (APL) accounts for 5–15% of acute myeloid leukemia cases. It is typically characterized by the (15;17) chromosomal translocation, producing the pathogenic retinoic acid receptor (RAR) alpha/promyelocytic leukemia (PML) fusion
Bojana Lucic +20 more
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Single-cell transcriptome sequencing reveals the mechanism of Realgar improvement on erythropoiesis in mice with myelodysplastic syndrome [PDF]
Cancer Cell InternationalMyelodysplastic syndrome (MDS) is a malignant hematologic disorder with limited curative options, primarily reliant on hematopoietic stem cell transplantation. Anemia, a prevalent symptom of MDS, has few effective treatment strategies.
Hao Xu +9 more
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The regulatory effects of realgar and cinnabar on glucose metabolism in mice [PDF]
Frontiers in EndocrinologyBackgroundGlucose metabolism plays a central role in maintaining systemic energy homeostasis, and its dysregulation is closely linked to the pathogenesis of metabolic diseases such as diabetes mellitus. While traditional mineral medicines such as realgar
Yifan Zhang +9 more
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Research progress on arsenic, arsenic-containing medicinal materials, and arsenic-containing preparations: clinical application, pharmacological effects, and toxicity [PDF]
Frontiers in PharmacologyIntroduction: The toxicity of arsenic is widely recognized globally, mainly harming human health by polluting water, soil, and food. However, its formulations can also be used for the clinical treatment of diseases such as leukemia and tumors.
Yichu Yang +7 more
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Science of Traditional Chinese Medicine, 2023 . Realgar is an arsenic-containing Chinese medicine known for its toxin-removing, phlegm-dispelling, and malaria-intercepting effects. It has proven to be effective in the treatment of acute promyelocytic leukemia.
Yan Yi +3 more
doaj +1 more source
Xanthine oxidase, a therapeutic target of realgar for non-small cell lung cancer
Heliyon, 2023 Background: The effects of realgar against non-small cell lung cancer (NSCLC) have been massively studied, but the direct therapeutic targets of realgar remain unclear.
Rui Guo +11 more
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