Results 61 to 70 of about 1,731 (192)

Heavy Metals Toxicity: Mechanism, Health Effects, and Therapeutic Interventions

MedComm, Volume 6, Issue 9, September 2025.
Heavy metals exert a wide range of effects at the cellular, molecular, and genetic levels, leading to neurological damage, renal dysfunction, cardiovascular disease, reproductive developmental abnormality, immune system abnormality, and increased risk of cancer by interfering with biomolecule function, signaling pathways, inducing oxidative stress, and
Yu‐feng Cheng, Yu‐jia Zhao, Ce Chen, Feng Zhang   +3 more
wiley   +1 more source

Toxicology Evaluation of Realgar-Containing Niu-Huang-Jie-Du Pian as Compared to Arsenicals in Cell Cultures and in Mice [PDF]

, 2011
Niu-Huang-Jie-Du Pian (NHJD) is a widely used traditional Chinese medicine containing realgar (As4S4). Realgar has been included in many traditional medicines, but is often taken as arsenite for risk assessment.
Shi-Xia Liang, Jie Liu, Jia-Wei Miao, Qin Wu, An-Sheng Sun   +4 more
core   +1 more source

Occurrence of realgar and orpiment in Utah [PDF]

American Journal of Science, 1881
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openaire   +1 more source

Ferroptosis in Haematological Malignancies: From Regulatory Networks to Novel Therapeutic Opportunities

Journal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT Haematological malignancies encompass a wide spectrum of blood cell disorders with diverse prognoses. Despite recent advances in therapy, many of these disorders remain incurable or exhibit relapse and drug resistance. Ferroptosis, an iron‐dependent form of cell death caused by lipid peroxidation, holds promise as a strategy to overcome the ...
Maryam Shayanmanesh, Seyed Esmaeil Ahmadi, Ali Amini   +2 more
wiley   +1 more source

Revisiting some overlooked registered Thai traditional medicine preparations: an alert to a regulatory affair

Bulletin of the National Research Centre, 2022
Objective This study evaluated the heavy metal identity and content of registered Thai Traditional medicine (TTM) preparations in Thailand to ensure consumer safety. Methods Both qualitative and quantitative information about the elemental composition of
Sornkanok Vimolmangkang, Dolly Rani, Naruemon Prestwong, Chayanis Sutcharitchan, Duangkamol Pakdeesattayapong   +4 more
doaj   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, Volume 12, Issue 31, August 21, 2025.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source

Mineral Arsenicals in Traditional Medicines: Orpiment, Realgar, and Arsenolite [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2008
Mineral arsenicals have long been used in traditional medicines for various diseases, yet arsenic can be highly toxic and carcinogenic. Arsenic in traditional medicines typically comes from deliberate addition for therapeutic purposes, mainly in the form of mineral arsenicals, including orpiment (As2S3), realgar (As4S4), and arsenolite (contains ...
Jie, Liu, Yuanfu, Lu, Qin, Wu, Robert A, Goyer, Michael P, Waalkes   +4 more
openaire   +2 more sources

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes (Adv. Sci. 29/2025)

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Acute Promyelocytic Leukemia The mineral realgar (As4S4), an orange‐brown painting pigment widely used in ancient Egypt, has recently become a valuable drug against acute promyelocytic leukemia (APL) in China. It mainly targets nuclear bodies (NB), altered in APL.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

Formation of realgar at the Mokrsko [PDF]

, 2014
Summary: Throughout the world there are many places with a high concentration of arsenic in water. In the Czech Republic is such a place the area of Mokrsko, where arsenic in groundwater reaches the values, which are well above recommended limits for ...
Rodovská, Zuzana
core  

An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway

, 2022
Realgar, a poisonous traditional Chinese medicine, has been shown to cause liver injury when used for long periods or overdoses. However, the underlying molecular mechanisms and therapeutic targets have not been fully elucidated. The aim of this study is
Guo, Haoqi, Haoqi Guo, Liu, Yu, Zhang, Yuwei, Taoguang Huo, Jing Yang, Yu Liu, Huo, Taoguang, Yuwei Zhang, Guo, Ziwei, Ziwei Guo, Jian Li, Yang, Jing, Li, Jian   +13 more
core   +1 more source