Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
User Experience Comparison of a Traditional Mannequin-Based and an Augmented Reality Lumbar Puncture Simulator in Geriatric Medicine Training: Questionnaire Study. [PDF]
JMIR XR Spat ComputCombret E +3 more
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Development and Initial Validation of High-Fidelity 3D Hybrid Simulators for Training in Complex Pediatric Oncologic Surgery. [PDF]
Cancers (Basel)Lustig P +4 more
europepmc +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
, 2005 This paper first revisits the discussion between Tony Lawson and Sandra Harding in the journal Feminist Economics in light of the author’s own research into basic mechanisms of capitalist economies, research that has been influenced by feminist ...
Brown, G. +2 more
core
Design of a multitissue osteoarticular 3D-Printed knee model for initial training in meniscal repair. [PDF]
SICOT JPignero M +7 more
europepmc +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
Ontic Structural Realism, Information, and Natural Necessity: Where Naturalism and Analytic Metaphysics Can Find Common Ground [PDF]
J. Ladyman (1998-2009), Ladyman and Ross (2007) refine J. Worral's (1998) structural realism (SR), by developing an ontic structural realism (OSR) which they argue is a consistently naturalistic means of characterizing the ontology of fundamental physics.
Kallfelz, William
core
Development and Educational Evaluation of a Radiation Visualization System in a Virtual Reality Training Module for Radiopharmaceutical Administration: Mixed Methods Study of Students' Learning Experiences. [PDF]
JMIR Med EducKakimoto A +6 more
europepmc +1 more source