Results 101 to 110 of about 577,749 (308)

The Comparison of Effectiveness of Acceptance-Commitment Therapy with Reality Therapy on Covert Relational Aggression in Women with Marital Burnout [PDF]

open access: yesروانشناسی بالینی و شخصیت
Introduction: The purpose of this study was to comparison of effectiveness of acceptance-commitment therapy with reality therapy on covert relational aggression in women with marital burnout.Method: This semi-experimental study employed a pretest ...
Abbas Tarighi Shadmahani   +2 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

The Effectiveness of Reality Therapy and Emotion-Focused Therapy on Cognitive Avoidance in Women with Marital Distress

open access: yesIranian Journal of Educational Research
Objective: The objective of the present investigation was to assess the efficacy of reality therapy and emotion-focused therapy in mitigating cognitive avoidance among women experiencing marital distress.
Maryam Toope   +2 more
doaj  

The Effectiveness of Reality Therapy Training on Marital Burnout in Couple with Marital Conflicts

open access: yesTaḥqīqāt-i ̒Ulūm-i Raftārī, 2020
Aim and Background: Burnout in couples is a gradual and rarely sudden process in which intimacy and love are gradually faded and general fatigue becomes evident.
Maryam Jafarimanesh   +3 more
doaj  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Pengembangan Website Cybercounseling Realita untuk Meningkatkan Keterbukaan Diri Siswa Sekolah Menengah Kejuruan

open access: yesJurnal Kajian Bimbingan dan Konseling, 2018
: This research and development aims to produce a cybercounseling reality website and a reality cybercounseling guidebook to improve self-disclosure for Vocational High School students which are grateful theoretically and practically.
Abi Fa'izzarahman Prabawa   +2 more
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Development and validation of the couple’s basic needs assessment scale

open access: yesمجله علوم روانشناختی, 2019
Background: The focus of reality therapy interventions in working with couples, is to raise couple’s awareness of their needs and to help them meet each other’s needs.
mona maaref   +3 more
doaj  

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