Results 71 to 80 of about 117,304 (262)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Iranian Journal of Educational ResearchObjective: The objective of the present investigation was to assess the efficacy of reality therapy and emotion-focused therapy in mitigating cognitive avoidance among women experiencing marital distress.
Maryam Toope +2 more
doaj
The Effectiveness of Reality Therapy Training on Marital Burnout in Couple with Marital Conflicts
Taḥqīqāt-i ̒Ulūm-i Raftārī, 2020 Aim and Background: Burnout in couples is a gradual and rarely sudden process in which intimacy and love are gradually faded and general fatigue becomes evident.
Maryam Jafarimanesh +3 more
doaj
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Jurnal Kajian Bimbingan dan Konseling, 2018 : This research and development aims to produce a cybercounseling reality website and a reality cybercounseling guidebook to improve self-disclosure for Vocational High School students which are grateful theoretically and practically.
Abi Fa'izzarahman Prabawa +2 more
doaj
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Development and validation of the couple’s basic needs assessment scale
مجله علوم روانشناختی, 2019 Background: The focus of reality therapy interventions in working with couples, is to raise couple’s awareness of their needs and to help them meet each other’s needs.
mona maaref +3 more
doaj
Comparison between the effects of group-based acceptance and commitment therapy and group-based reality therapy on work-family conflict & psychological well-being of married female staffs [PDF]
مجله علمی دانشگاه علوم پزشکی کردستان, 2019 Background and Aim: Administration of the therapy protocols can increase psychological well-being with resultant decrease in the work-family conflict. The purpose of this study was to make a comparison between the effects of group-based acceptance and ...
Hajikaram A, Ghamari M, Amiri Majd M
doaj
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source