Results 91 to 100 of about 20,602 (293)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan   +9 more
wiley   +1 more source

On the Role of Absorptive Capacity: FDI Matters to Growth [PDF]

open access: yes, 2006
The paper studies the effects of foreign direct investment (FDI) on economic growth when sufficient provisions of infrastructure is a pre-requisite. In the overlapping generations setting, we show that technology spillovers via FDI take place only when ...
Kinoshita, Yuko, Lu, Chia-Hui
core   +1 more source

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

open access: yesArthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier   +12 more
wiley   +1 more source

Evaluation of the Potential of Laser Shock Peening Compared with Cold Expansion for Improving Fatigue Resistance of Riveted Lap Joints of Aerospace Grade 7175 Al Alloy

open access: yesAdvanced Engineering Materials, EarlyView.
This study investigates laser shock peening for enhancing fatigue performance of riveted aerospace aluminum joints. A comparative approach with cold expansion combines fatigue testing and synchrotron X‐ray methods. Integrating mechanical testing with residual stress and strain characterization provides insights into how different treatments affect the ...
Ogün Baris Tapar   +6 more
wiley   +1 more source

Impact of Alliances on Technological Performance of Local Companies in Emerging Markets: Case of Tunisian Firms. [PDF]

open access: yes
The evolution of co-operations between firms has permitted a plentiful literature around the conception of the firm and its frontiers and has placed the specificity of competencies and innovation in the heart of the firm analysis.
Benslimane, Sonia
core  

Regional Specialization as a Driver of Potential and Realized Absorptive Capacity and Business Innovation

open access: yesJournal of the Knowledge Economy
Abstract This research aims to study the influence of regional agglomeration on business innovation and the effect of absorptive capacity as a mediating variable in this relationship. The investigation has been developed using a sample of 197 firms of the energy sector, from which were obtained primary data that was analyzed using the PLS-SEM
Eduardo Sánchez-García   +3 more
openaire   +2 more sources

On the Lightweight Potential of Laser Additive Manufactured NiTi Triply Periodic Minimal Sheet Lattices

open access: yesAdvanced Engineering Materials, EarlyView.
This study explores the lightweight potential of laser additive‐manufactured NiTi triply periodic minimal surface sheet lattices. It systematically investigates the effects of relative density and unit cell size on surface quality, deformation recovery, compression behavior, and energy absorption.
Haoming Mo   +3 more
wiley   +1 more source

Laser Powder Bed Fusion of Copper–Tungsten Composites for Heat Sink Applications in High‐Power Electronics

open access: yesAdvanced Engineering Materials, EarlyView.
This article demonstrates the successful qualification of a copper–tungsten composite for laser powder bed fusion. The resulting components exhibited high density, high thermal conductivity, and reduced thermal expansion. Heat sinks with complex geometries were successfully manufactured, clearly showcasing the material's potential for additive ...
Simon Rauh   +6 more
wiley   +1 more source

Open Innovation, ambiguity and technological convergence [PDF]

open access: yes, 2017
Objectives. Current paper aims to provide a fresh conceptual framework on the relationship among open innovation, decision ambiguity, and technological convergence.
Ferri, M. A.   +3 more
core  

Effects of entrepreneurial decision-making on the realized absorptive capacity of knowledge-intensive companies

open access: yesInternational Journal of Innovation
Objective: To investigate how entrepreneurial decision-making influences the relationship between Potential Absorptive Capacity (PACAP) and Realized Absorptive Capacity (RACAP) in knowledge-intensive companies engaged in public innovation policies.
Tiago André Portela Martins   +4 more
openaire   +1 more source

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