Results 101 to 110 of about 54,234 (265)

Rethinking Reanalysis

JAMA, 2013
Christakis, Dimitri A, Zimmerman, Frederick J   +1 more
openaire   +5 more sources

Developing a Typology of Korean Women Leaders' Resistance to Their Token Status in the Workplace

Human Resource Development Quarterly, EarlyView.
ABSTRACT Despite remarkable economic development in South Korea (Korea), there are only a few women leaders, and they face challenges in the gendered workplace where organizational constraints and traditional values coexist. In a reanalysis of narratives of Korean women leaders (KWLs), using an ideal‐type analysis as a novel qualitative research method,
Yonjoo Cho, Jiwon Park, Sumi Lee, Jieun You, Sokyum Yoon   +4 more
wiley   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome

iMetaOmics, EarlyView.
A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng, Ling Yan, Yilin Wu, Yan Li, Ziheng Ye, Zhen Zhang, Yi Zhang, Jingyun Ma, Yuhong Liang, Zhaofan Luo, Huacheng Wang, Meili Gao, Chao Qin, Ke Zhu, Yun Leng, Kamran Ullah, Jun Liang, Haiyan Yan, Guan Yang, Yingqian Mo, Bihui Huang   +20 more
wiley   +1 more source

Warm‐wet transition restructures arid lake microbiomes and functional potential

iMetaOmics, EarlyView.
This study summarizes how a long‐term warm‐dry to warm‐wet transition restructures microbiomes and functional potential in Lake Bosten, an arid lake in northwestern China. Warm‐wet hydroclimatic change increased water level and hydrological connectivity, while decreasing salinity and total nitrogen.
Zhen Shen, Xingchen Li, Zhijun Gong, Yang Hu, Yongjiu Cai, Keqiang Shao, Guang Gao, Robbie M. Martin, Xiangming Tang   +8 more
wiley   +1 more source

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

Drought Risk in Mango and Avocado Orchards: Insights Into Plant Water Relations and Irrigation‐Related Agronomic Solutions

Irrigation and Drainage, EarlyView.
ABSTRACT Climate change is making water availability more uncertain, with growing consequences for the productivity and long‐term sustainability of tropical and subtropical fruit orchards. Mangifera indica L. and Persea americana Mill. both require large amounts of water to sustain growth and productivity.
Eleonora Cataldo
wiley   +1 more source

Not Missing the Notch: Detection Challenges of Juxtamembrane NOTCH1 Variant Detection in T‐Cell Acute Lymphoblastic Leukemia

Journal of Clinical Laboratory Analysis, EarlyView.
ABSTRACT Background Activating mutations in NOTCH1 are frequent in T‐cell acute lymphoblastic leukemia (T‐ALL) and, in the absence of alterations in RAS or PTEN, are associated with favorable prognosis. Besides classical heterodimerization and PEST domain mutations, juxtamembrane internal tandem duplications (JME‐ITDs) represent a third class of ...
Francisco Beas, Stephan Hutter, Ferran Balbastre‐Úbeda, Sandra Novoa‐Jáuregui, Maria Gabarrós‐Subirà, Eulalia Genescà, Petri Pölönen, Torsten Haferlach, Andrés Jerez   +8 more
wiley   +1 more source

Bridging Bystander Intervention and Workplace Inclusion: The Critical Role of Perceived Fairness, Support, and Safety

Journal of Organizational Behavior, EarlyView.
ABSTRACT Bystander intervention is widely assumed to foster workplace inclusion, yet no studies have directly examined this relationship. Through abductive qualitative analysis of 53 interviews across two contrasting organisations—a consulting firm and a remote mine site—we investigate how bystander intervention relates to workplace inclusion for ...
Laura Jennings, Kun Zhao, Liam Smith, Denise Goodwin, Nicholas Faulkner   +4 more
wiley   +1 more source

Assessing the Performance of the Copernicus European Regional Reanalysis Dataset in Reproducing Extreme Weather Events in Poland

International Journal of Climatology, EarlyView.
Global reanalyses, for example ERA5 and ERA5‐Land, tend to misrepresent the local‐scale weather extremes due to the limited spatial resolution. In this paper CERRA shows clear and consistent improvements over ERA5 and ERA5‐Land in representing extreme temperature and precipitation in Poland, particularly for localized and short‐lived heavy rainfall ...
Kinga Kulesza, Maciej Jefimow, Joanna Strużewska   +2 more
wiley   +1 more source