Results 51 to 60 of about 128,938 (302)
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo +10 more
wiley +1 more source
Robustness of serial clustering of extratropical cyclones to the choice of tracking method
Cyclone clusters are a frequent synoptic feature in the Euro-Atlantic area. Recent studies have shown that serial clustering of cyclones generally occurs on both flanks and downstream regions of the North Atlantic storm track, while cyclones tend to ...
Joaquim G. Pinto +5 more
doaj +1 more source
The development of winter ski tourism and characteristics of ski resorts in various regions of Russia are closely related to climatic conditions, the most important of which are the presence and duration of snow cover.
V. V. Vinogradova, T. B. Titkova
doaj +1 more source
UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma +14 more
wiley +1 more source
Decreases in terrestrial near-surface wind speed ( NSWS ) were documented in many regions over the past decades. Various drivers have been proposed for this terrestrial stilling, such as weakening of ocean-land pressure gradients related to climate ...
Jun Wang +4 more
doaj +1 more source
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang +7 more
wiley +1 more source
Deepwater Physical Oceanography Reanalysis and Synthesis of Historical Data: Synthesis Report [PDF]
Summary describing the work completed at Texas A&M University for 'Deepwater Physical Oceanography Reanalysis and Synthesis of Historical Data.' It includes background information on the project funding and sponsorship, goals, methodology, and ...
Texas A & M University
core
Recent biennial variability of meteorological features in the Eastern Highland Himalayas [PDF]
With meteorological data from high altitude surface stations and gridded dataset from NCEP/NCAR Reanalysis, a biennial oscillation over the Eastern Highland Himalayas from 1980 to 1998 is described.
Tartari, G +5 more
core +1 more source
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang +11 more
wiley +1 more source
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen +13 more
wiley +1 more source

