Results 51 to 60 of about 51,523 (265)

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Editorial: Recent advances in climate reanalysis

Frontiers in Climate, 2023
Yiguo Wang, Xingren Wu, Lipeng Jiang, Fei Zheng, Sebastian Brune   +4 more
doaj   +1 more source

Ivermectin, A Reanalysis of the Data

American Journal of Therapeutics, 2021
Paul E. Marik, Pierre Kory
openaire   +3 more sources

Low Latency Global Carbon Budget Reveals Late 2024 Carbon Losses and Contrasting Early 2025 Land Sink Recovery Signals

Advanced Science, EarlyView.
Low latency carbon budget estimates for July 2024–June 2025 combine atmospheric CO2 growth rates, fossil emissions, ocean uptake, DGVM land fluxes, and OCO‐2 inversions. The budget shows that late‐2024 land carbon losses dominate the annual anomaly, while early‐2025 recovery differs between bottom‐up models and top‐down inversions, especially in ...
Piyu Ke, Philippe Ciais, Yitong Yao, Stephen Sitch, Wei Li, Xiaomeng Du, Xiaofan Gui, Ben Poulter, Thomas Colligan, Auke M. van der Woude, Joram Hooghiem, Wouter Peters, Zhu Liu, Zhu Deng, Zhe Jin, Xiangjun Tian, Yilong Wang, Junjie Liu, Sudhanshu Pandey, Chris O'Dell, Jiang Bian, John Miller, Xin Lan, Jefferson Goncalves De Souza, Michael O'Sullivan, Pierre Friedlingstein, Julien Alléon, Yi Xi, Daniel S. Goll, Lei Zhu, Guido R. van der Werf, Shilong Piao, Frédéric Chevallier   +32 more
wiley   +1 more source

Performance Assessment of Dynamic Downscaling of WRF to Simulate Convective Conditions during Sagebrush Phase 1 Tracer Experiments

Atmosphere, 2018
Large-Eddy Simulations (LES) corresponding to four convective intensive observation periods of Sagebrush Phase 1 tracer experiment were conducted with realistic boundary conditions using Weather Research and Forecast model (WRF).
Sudheer R. Bhimireddy, Kiran Bhaganagar
doaj   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

CONSTRUCTION OF A SPATIAL DISTRIBUTION MODEL OF WIND ENERGY CHARACTERISTICS

Сучасні інформаційні системи
The aim of this article is to develop a model for the spatial distribution of wind energy characteristics across the territory of Ukraine. The subject of the study includes datasets of wind speed values, as well as methods of data correlation ...
Nataliia Ausheva , Svitlana Shapovalova , Kateryna Petrenko , Oleksandr Kardashov , Anton Sofiienko   +4 more
doaj   +1 more source

The Interoperability Challenge in DFT Workflows Across Implementations

Advanced Intelligent Discovery, EarlyView.
Interoperability and cross‐validation remain major challenges in the computational materials science. In this work, we introduce a common input/output standard that enables internal translation across multiple workflow managers—AiiDA, PerQueue, Pipeline Pilot, and SimStack—while producing results in a unified schema.
Simon K. Steensen, Tushar Singh Thakur, Manuel Dillenz, Johan M. Carlsson, Celso R. C. Rêgo, Eibar Flores, Hamidreza Hajiyani, Felix Hanke, Juan María García Lastra, Wolfgang Wenzel, Nicola Marzari, Tejs Vegge, Giovanni Pizzi, Ivano E. Castelli   +13 more
wiley   +1 more source

Short-Term Wind Energy Yield Forecasting: A Comparative Analysis Using Multiple Data Sources

Energies
Short-term wind turbine energy yield forecasting is crucial for effectively integrating wind energy into the electricity grid and fulfilling day-ahead scheduling obligations in electricity markets such as Nord Pool and EPEX SPOT.
Nikita Dmitrijevs, Vitalijs Komasilovs, Svetlana Orlova, Edmunds Kamolins   +3 more
doaj   +1 more source

Null subjects: a reanalysis of the data

Linguistics, 2009
In the face of problems with previous syntactic theories, this article 1 establishes a new concept relating to the incidence of null thematic pronouns, focusing on null thematic subjects. The data indicate that, in rich agreement languages with null subjects, prima facie, recovery of such subjects is achieved first by reference to discrete agreement ...
openaire   +1 more source