Results 101 to 110 of about 593,969 (248)

A study on the Reasonable Accommodation Duty and the Job Accommodation Scheme for People with Disabilities

, 2018
2007년 제정된 장애인차별금지법은 특히 정당한 편의제공 의무를 통해 장애인의 노동시장 통합에 크게 기여할 것으로 기대되었다. 하지만 시행 10년이 지난 현재 실질적인 파급 효과는 크지 않은 것으로 평가된다. 정당한 편의제공 의무는 ‘과도한 부담’이라는 면제 조건을 갖기 때문에 실효성 강화를 위해서는 의무 이행을 위한 지원 제도의 마련과 법적 관계 설정이 중요할 수 있다.
심재진, 김성희, 서정희, 오다은, 오욱찬   +4 more
core  

REASONABLE ACCOMMODATION, ADVERSE ACTION AND THE CASE OF DEBORAH SCHOU

, 2012
REASONABLE ACCOMMODATION, ADVERSE ACTION AND THE CASE OF DEBORAH ...
Anna Chapman (13062876)
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Development of the Reasonable Accommodation Factor Survey: Results and Implications

, 2010
The purpose of this study was (a) to explore the latent factors in the Reasonable Accommodation Factor Survey (RAFS) instrument and (b) to compare scores on the latent factors of the RAFS by participant's role.
Fabian, Ellen, Shengli Dong, MacDonald-Wilson, Kim L., Ellen Fabian, Kim L. MacDonald-Wilson, Shengli Dong,   +5 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Workforce Transition and Job Accessibility among Ethiopian People with Disabilities: A Cross-Sectional Survey

Scandinavian Journal of Disability Research
Background: In Ethiopia, people with disabilities (PwDs) face significant marginalization and barriers to employment, despite a legislative framework intended to guarantee their rights.
Tsega Hagos Mirach, Rosemary M. Lysaght, Molalign Belay Adugna, Abebe Assefa Alemu, Meseret Hassen Ayele, Sewbesew Yitayih Tilahun, Tewelde Gebremariam Adhanom, Abayneh Gujo Desta   +7 more
doaj   +1 more source

Employer duties towards pregnant and lactating employees in the hospitality industry in South Africa. [PDF]

African Journal of Hospitality, Tourism and Leisure, 2016
The hospitality industry or sector in South Africa is characterised by the employment of unskilled mainly young female employees. Consequently, it is inevitable that many of these employees will at some time be pregnant or lactating.
Professor Advocate Stella Vettori
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source