Results 81 to 90 of about 23,193 (292)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Reasonable Provocation and Self-Defense: Recognizing the Distinction Between Act Reasonableness and Emotion Reasonableness [PDF]
, 2009 This brief essay, written for the Criminal Law Conversations project, argues that the doctrines of provocation and self-defense should recognize a distinction between act reasonableness and emotion (or belief) reasonableness.
Lee, Cynthia
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Fair trial in the torus of digital managerialism of the criminal system
حقوق فناوریهای نوینThe discussion of civil liability arising from algorithmic losses - which is mostly investigated as civil liability of artificial intelligence or liability arising from the use of artificial intelligence is nascent /aborning in the legal literature ...
Azim Aghababaei Taghanaki +1 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
حقوق فناوریهای نوینThe discussion of civil liability arising from algorithmic losses - mostly investigated as civil liability of artificial intelligence or liability arising from the use of artificial intelligence is nascent /aborning in the legal literature.
Haniyeh Zakerinia, Zahra Gholampour
doaj
Reasonableness in the Concept of Reasonable Accommodation
Age of Human Rights Journal, 2016 Reasonable accommodation is one of the pillars upon which the recognition of the rights of people with disabilities rests. It acquires its full meaning when understood in connection with the concept of universal design, since both concepts fall within ...
Rafael de Asís Roig
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Substantive Review in Appellate Courts since Dunsmuir
Osgoode Hall Law Journal, 2009 In Dunsmuir v. New Brunswick, the Supreme Court re-examined its approach to judicial review of administrative decisions to develop a "more coherent and-workable" framework.
Gerald P. Heckman
doaj +1 more source
, 2020 Safety Instrumented Systems (SIS) protect major hazard facilities, e.g. power plants, against catastrophic accidents. An SIS consists of hardware components and a controller software -- the ``program''. Current safety analyses of SIS' include the construction of a fault tree, summarising potential faults of the components and how they can arise within ...
Hamid Jahanian, Annabelle McIver
openaire +2 more sources