Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
TraVLR: Now You See It, Now You Don't! A Bimodal Dataset for Evaluating Visio-Linguistic Reasoning [PDF]
, 2021 Keng Ji Chow, Samson Tan, Min‐Yen Kan
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Engaging astronomy students online with scientific reasoning about real data [PDF]
, 2022 Jeffrey Hyde
openalex +1 more source
Reasoning About Liquids via Closed-Loop Simulation
, 2017 Simulators are powerful tools for reasoning about a robot's interactions with its environment. However, when simulations diverge from reality, that reasoning becomes less useful.
Fox, Dieter, Schenck, Connor
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Homo Promptus: Predicting the impact of generative AI on human memory and creativity
Memory, Mind & MediaThis article explores the transformational potential of artificial intelligence (AI), particularly generative AI (genAI) – large language models (LLMs), chatbots, and AI-driven smart assistants yet to emerge – to reshape human cognition, memory, and ...
Katerina Linden +2 more
doaj +1 more source
Logic Negation with Spiking Neural P Systems
, 2019 Nowadays, the success of neural networks as reasoning systems is doubtless. Nonetheless, one of the drawbacks of such reasoning systems is that they work as black-boxes and the acquired knowledge is not human readable.
Borrego-Díaz, Joaquín +2 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source