Results 71 to 80 of about 738,099 (298)
Transportation Research Interdisciplinary Perspectives, 2019 When studying real-world infrastructure systems as networks, one common avenue of analysis is the identification of critical network elements. These features are often defined as the nodes or edges in a given network that play an outsized role in the ...
Edward Helderop, Tony H. Grubesic
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Clinical reasoning for manual therapists
, 2004 A practical text covering the theory and the practice of clinical reasoning skills for all physical therapists. Provides readers with activities to improve their own clinical reasoning within their own clinical setting.
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
, 2020 Safety Instrumented Systems (SIS) protect major hazard facilities, e.g. power plants, against catastrophic accidents. An SIS consists of hardware components and a controller software -- the ``program''. Current safety analyses of SIS' include the construction of a fault tree, summarising potential faults of the components and how they can arise within ...
Hamid Jahanian, Annabelle McIver
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Reasoning over Spatial Orientation Relations Using Rules [PDF]
Representation of spatial information for the Semantic Web often involves qualitative defined information (i.e., information described using natural language terms such as "Left"), since precise arithmetic descriptions using coordinates and angles are
Tachmazidis, Ilias +2 more
core +3 more sources
Towards LarKC: a Platform forWeb-scale Reasoning [PDF]
, 2008 Current Semantic Web reasoning systems do not scale to the requirements of their hottest applications, such as analyzing data from millions of mobile devices, dealing with terabytes of scientific data, and content management in enterprises with thousands
Andersson, B. +47 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source