Results 61 to 70 of about 275,206 (269)

AI-Driven Durian Leaf Disease Classification Using Benchmark CNN Architectures for Precision Agriculture

Applied Sciences
Durian (Durio zibethinus Murray) is Thailand’s most economically significant fruit export, yet foliar diseases pose a major threat to productivity and crop quality.
Rapeepat Klangbunrueang, Wirapong Chansanam, Natthakan Iam-On, Tossapon Boongoen   +3 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Deconstructing the seductive allure of neuroscience explanations

Judgment and Decision Making, 2015
Previous work showed that people find explanations more satisfying when they contain irrelevant neuroscience information. The current studies investigate why this effect happens.
Deena Skolnick Weisberg, Jordan C. V. Taylor, Emily J. Hopkins   +2 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Reasoning with Failures

, 2020
Safety Instrumented Systems (SIS) protect major hazard facilities, e.g. power plants, against catastrophic accidents. An SIS consists of hardware components and a controller software -- the ``program''. Current safety analyses of SIS' include the construction of a fault tree, summarising potential faults of the components and how they can arise within ...
Hamid Jahanian, Annabelle McIver
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Conclusions by analogy and their place in diagnostics

Бюллетень сибирской медицины, 2003
In the article the main point of conclusions by analogy as a kind of logical reasoning and their cognitive value are analyzed. The place of these conclusions in doctor’s thinking is examined.
E. M. Doon
doaj   +1 more source

Reasons as Premises of Good Reasoning [PDF]

Pacific Philosophical Quarterly, 2015
AbstractMany philosophers have been attracted to the view that reasons are premises of good reasoning – that reasons to φ are premises of good reasoning towards φ‐ing. However, while thisreasoning viewis indeed attractive, it faces a problem accommodating outweighed reasons.
openaire   +3 more sources