Results 221 to 230 of about 3,704,431 (305)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Investigation of the Reasons for the Non-Return of Lapsed Blood Donors: A Qualitative Study. [PDF]

Health Sci Rep
Javadzadeh Shahshahani H, Fattahi Ardakani M, Amiri F, Kazemi S, Heydari S, Zareipour M, Meybody SMA, Rointan H, Vaziri M.   +8 more
europepmc   +1 more source

Suspension of judgment, hinge style. [PDF]

Synthese
Piedrahita OA, Schmidt S.
europepmc   +1 more source

Nomothetic and idiographic determinants of dietary lapses and adherence: an exploratory mixed methods ecological momentary assessment study of open-text responses. [PDF]

Front Nutr
van Alebeek H, Schröder A, John D, Probst T.   +3 more
europepmc   +1 more source

Blood Donor Deferral Patterns at a Tertiary Care Hospital in Central India: A Retrospective Cross-Sectional Study. [PDF]

Cureus
Dad A, Patidar SK, Likhar KS, Gujar RK.
europepmc   +1 more source

The global landscape of pediatric monoclonal antibody (mAb) clinical trials: an analysis of ClinicalTrials.gov. [PDF]

Front Pediatr
Sharma A, Mukherjee S, Lynch S.
europepmc   +1 more source