Results 151 to 160 of about 785,607 (304)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Reasons of Emotional Conditions of Police Officers in Conflict Situations
, 2007 The object of investigation is to analyse the reasons and the ways of solution of conflicts between a person d a police officer. 120 first-year students (60 girls and 60 boys) from Mykolas Romeris University Kaunas faculty of Police took part in the ...
Muliarčikas, Algirdas +1 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Reasons and Victims of Honour Killing in Pakistan: An Analysis
, 2019 Honour killing in Pakistan is a very critical issue which is being echoed throughout the world. Parallel to it are the governmental claims that this issue has been addressed, by enhancing the representation in the legislature assemblies and by the strict
Ishtiaq Ahmad Choudhry; Professor of International Relations Lahore Garrison University, Lahore. +2 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Self-inconsistency and attachment insecurity mediate and moderate the association between anxiety and reasons for living in Chinese college students. [PDF]
Sci RepLi L, Zhao X, Ding X.
europepmc +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Poverty Dynamics, Violent Conflict and Convergence in Rwanda [PDF]
Civil war and genocide in the 1990-2000 period in Rwanda - a small, landlocked, densely populated country in Central Africa - have had differential economic impacts on the country’s provinces.
Philip Verwimp, Patricia Justino
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