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Reassortment events in the evolution of hantaviruses [PDF]
Virus Genes, 2018 Hantaviruses (order Bunyavirales, family Hantaviridae), known as important zoonotic human pathogens, possess the capacity to exchange genome segments via genetic reassortment due to their tri-segmented genome. Although not as frequent as in the arthropod-borne bunyaviruses, reports indicating reassortment events in the evolution of hantaviruses have ...
Boris Klempa, Klempa Boris
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Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment [PDF]
Molecular Biology and Evolution, 2015 Influenza A virus (IAV) has a segmented genome that allows for the exchange of genome segments between different strains. This reassortment accelerates evolution by breaking linkage, helping IAV cross species barriers to potentially create highly ...
Konstantin B Zeldovich +2 more
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Constraints, Drivers, and Implications of Influenza A Virus Reassortment
Annual Review of Virology, 2017 Influenza A viruses are constantly changing. This change accounts for seasonal epidemics, infrequent pandemics, and zoonotic outbreaks. A major mechanism underlying the genetic diversification of influenza A virus is reassortment of intact gene segments
Anice C Lowen
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Journal of Virology, 2018 Exchange of gene segments through reassortment is a major feature of influenza A virus evolution and frequently contributes to the emergence of novel epidemic, pandemic, and zoonotic strains.
Mathilde Richard +2 more
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UBIQUITOUS REASSORTMENTS IN INFLUENZA A VIRUSES
Journal of Bioinformatics and Computational Biology, 2008The influenza A virus is a negative-stranded RNA virus composed of eight segmented RNA molecules, including polymerases (PB2, PB1, PA), hemagglutinin (HA), nucleoprotein (NP), neuraminidase (NA), matrix protein (MP), and nonstructure gene (NS).
Xiu-Feng Wan, Mufit Ozden, Guohui Lin
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Influenza A Virus Reassortment
2014Reassortment is the process by which influenza viruses swap gene segments. This genetic exchange is possible due to the segmented nature of the viral genome and occurs when two differing influenza viruses co-infect a cell. The viral diversity generated through reassortment is vast and plays an important role in the evolution of influenza viruses ...
John, Steel, Anice C, Lowen
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Is rotavirus a population of reassortants?
Trends in Microbiology, 1995Rotaviruses appear to exist as heterogeneous populations of reassortants and related variants. This phenomenon is consistent with the quasispecies concept of RNA viruses, and suggests that gene reassortment is a crucial evolutionary mechanism for this segmented virus.
V, Gouvea, M, Brantly
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Frequency and patterns of reassortment in natural influenza A virus infection in a reservoir host
Virology, 2013 Influenza A viruses (IAV) can dramatically alter both genotype and phenotype at a rapid rate as a product of co-infection and reassortment Avian IAV exhibit high levels of phylogenetic incongruence, suggesting high levels of reassortment in the virus ...
Michelle Wille +2 more
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WC3 reassortant vaccines in children
1996Bovine rotavirus strain WC3 (P7[5], G6) administered at the 12th passage level was well tolerated clinically in infants and efficiently induced serum virus neutralizing antibody (VNA) with bovine rotavirus G6 specificity. The protective efficacy of WC3 vaccine against all rotavirus disease was inconsistent, varying in four separate trials from 76% to 0%
H F, Clark +7 more
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Reassortment among picobirnaviruses found in wolves
Archives of Virology, 2016We conducted a viral metagenomics study in diarrheic free-ranging wolves in Portugal, revealing for the first time the presence of reassortant picobirnaviruses. These viruses shared identical capsid segments together with diverse RNA-dependent RNA polymerase segments.
Conceição-Neto, Nádia +10 more
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