Results 21 to 30 of about 1,343 (129)

Characteristics of Attenuating Effects of Rebamipide, an Anti-ulcer Agent, on Oxidative Burst of Human Neutrophils

Journal of Pharmacological Sciences, 2003
The aim of this study was to characterize the effects of rebamipide on the oxidative burst of human neutrophils. The neutrophil oxidative burst was measured in the presence of rebamipide and cimetidine using lucigenin- or luminol-dependent ...
Tadashi Shimoyama, Shinsaku Fukuda, Qiang Liu, Yoshihiro Fukuda, Shigeyuki Nakaji, Kazuo Sugawara   +5 more
doaj   +1 more source

Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis. [PDF]

PLoS ONE, 2016
Temporomandibular joint osteoarthritis (TMJ-OA) is characterized by progressive degradation of cartilage and changes in subchondral bone. It is also one of the most serious subgroups of temporomandibular disorders.
Takashi Izawa, Hiroki Mori, Tekehiro Shinohara, Akiko Mino-Oka, Islamy Rahma Hutami, Akihiko Iwasa, Eiji Tanaka   +6 more
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Rebamipide ameliorates atherosclerosis by controlling lipid metabolism and inflammation. [PDF]

PLoS ONE, 2017
The oral administration of rebamipide decreased plaque formation in atherosclerotic lesions as well as the markers of metabolic disorder in ApoE-deficient mice with atherosclerosis. Pro-inflammatory cytokines were also suppressed by rebamapide.
JooYeon Jhun, Jeong-Eun Kwon, Se-Young Kim, Jeong-Hee Jeong, Hyun Sik Na, Eun-Kyung Kim, Seung Hoon Lee, KyungAh Jung, Jun-Ki Min, Mi-La Cho   +9 more
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Effects of Rebamipide on Gastrointestinal Symptoms in Patients with Type 2 Diabetes Mellitus [PDF]

Diabetes & Metabolism Journal, 2016
BackgroundGastrointestinal (GI) symptoms are common in patients with type 2 diabetes mellitus (T2DM). Rebamipide is an effective gastric cytoprotective agent, but there are few data on its usefulness in T2DM.
Sejeong Park, So Young Park, Yu Jin Kim, Soo Min Hong, Suk Chon, Seungjoon Oh, Jeong-taek Woo, Sung-Woon Kim, Young Seol Kim, Sang Youl Rhee   +9 more
doaj   +1 more source

Rebamipide does not interfere with the antitumor effect of radiotherapy or chemotherapy in human oral tumor-bearing nude mice

Journal of Pharmacological Sciences, 2015
Recent studies have shown that rebamipide, which suppresses reactive oxygen species, prevents chemoradiotherapy-induced oral mucositis in patients with head and neck cancers.
Masafumi Shibamori, Masayuki Sato, Naoya Uematsu, Takako Nakashima, Asuka Sato, Yoshiya Yamamura, Hiroyuki Sasabe, Ken Umehara, Kazushi Sakurai   +8 more
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A simple high performance liquid chromatography method for determination of rebamipide in rat urine

MethodsX, 2014
Rebamipide is a mucoprotective agent commonly used to prevent nonsteriodal anti-inflammatory drug-induced gastrointenstinal side effects [1]. Human plasma and urine analysis of rebamipide utilizing high performance liquid chromatography (HPLC) have been ...
Dustin L. Cooper, Sam Harirforoosh
doaj   +1 more source

Rebamipide using in gastroesophageal reflux disease treatment

Терапевтический архив, 2020
Rebamipide is a mucoprotective drug which was developed in Japan in 1990. The therapeutic effect of rebamipide based on the induction of cyclooxygenase-2 and increasing level of prostaglandins, inhibition of oxygen free radicals production, epidermal ...
V. T. Ivashkin, A. S. Trukhmanov, M. I. Gonik   +2 more
doaj   +1 more source

Rebamipide Promotes the Regeneration of Aspirin-Induced Small-Intestine Mucosal Injury through Accumulation of β-Catenin. [PDF]

PLoS ONE, 2015
The effect of rebamipide on repairing intestinal mucosal damage induced by nonsteroidal anti-inflammatory drugs and its mechanism remain unclear. In this study, we sought to explore the mechanism whereby rebamipide could promote the regeneration of ...
Yu Lai, Wa Zhong, Tao Yu, Zhong-Sheng Xia, Jie-Yao Li, Hui Ouyang, Ti-Dong Shan, Hong-Sheng Yang, Qi-Kui Chen   +8 more
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Case Report: A Rare Orbital Abscess Caused by Dacryocystitis After Administration of Rebamipide Ophthalmic Suspension

Frontiers in Medicine, 2021
Background: Rebamipide ophthalmic suspension was launched in Japan in 2012 and is used for the treatment of dry eye.Case Presentation: We report two cases of orbital abscess, which resulted from dacryocystitis that occurred after administration of ...
Hitoshi Imamura, Hiroshi Eguchi, Masuo Sakamoto, Fumika Hotta, Hitoshi Tabuchi, Hitoshi Tabuchi, Shunji Kusaka   +6 more
doaj   +1 more source

Effectiveness and Safety of First-Line Empirical Eradication Therapy with Rebamipide: Results from the European Registry on Helicobacter pylori Management (Hp-EuReg)

Antibiotics
Background/Objective: Eradication of Helicobacter pylori typically uses acid-suppressing agents plus antimicrobials, but treatment failure may reach 20–30%. Adjunctive rebamipide has been proposed as a strategy to improve treatment outcomes.
Dmitry S. Bordin, Dmitrii N. Andreev, Sayar R. Abdulkhakov, Irina N. Voynovan, Igor G. Bakulin, Natalia V. Bakulina, Ludmila G. Vologzhanina, Boris D. Starostin, Aiman S. Sarsenbayeva, Tatyana A. Ilchishina, Larisa V. Tarasova, Alla G. Kononova, Sergey A. Alekseenko, Oleg V. Zaytsev, Natalya N. Dekhnich, Pavel O. Bogomolov, Galina N. Tarasova, Olga A. Kolokolnikova, Igor B. Khlynov, Ekaterina Yu. Plotnikova, Natalia V. Baryshnikova, Maria A. Livzan, Marina F. Osipenko, Natalya V. Bakanova, Ekaterina V. Partsvania-Vinogradova, Margarita V. Chebotareva, Rustam A. Abdulkhakov, Inna V. Savilova, Anastasia G. Sushilova, Sergey V. Kolbasnikov, Alsu R. Khurmatullina, Igor V. Maev, Maria O. Tishchenko, Rimma E. Petrova, Ludmila V. Morkovkina, Yulia V. Tsyganova, Margarita D. Kozlova, Aleksei A. Iakovlev, Alexander S. Volkov, Elizaveta S. Moroz, Olga V. Gaus, Singla Alba, Oriol Farrés, Leticia Moreira, Pablo Parra, Olga P. Nyssen, Francis Megraud, Colm O’Morain, Javier P. Gisbert   +48 more
doaj   +1 more source