Results 91 to 100 of about 8,181,745 (306)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency

Neuroscience Research
Transcranial alternating current stimulation (tACS) can modulate endogenous brain oscillations in a frequency-specific manner. Previous studies have reported that beta tACS modulates the excitability of primary motor cortex and improves task performance.
Mayu Akaiwa, Ryo Kurokawa, Yuya Matsuda, Yasushi Sugawara, Rin Kosuge, Hidekazu Saito, Eriko Shibata, Takeshi Sasaki, Kazuhiro Sugawara   +8 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Polygenic prediction of body mass index and obesity through the life course and across ancestries

Nature Medicine
Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European ...
R. A. Smit, K. Wade, Qin Hui, J. Arias, Xianyong Yin, M. Christiansen, L. Yengo, Michael H. Preuss, M. Nakabuye, G. Rocheleau, Sarah E. Graham, Victoria L. Buchanan, G. Chittoor, M. Graff, M. Guindo-Martínez, Yingchang Lu, E. Marouli, Saori Sakaue, C. Spracklen, S. Vedantam, Emmaleigh Wilson, Shyh-Huei Chen, T. Ferreira, Yingjie Ji, T. Karaderi, K. Lüll, Moara Machado, D. Malden, C. Medina-Gomez, Amy Moore, S. Rüeger, M. Akiyama, Matthew A. Allison, M. Alvarez, M. K. Andersen, Vivek Appadurai, L. Arbeeva, Eric Bartell, Seema Bhaskar, L. Bielak, J. Bis, S. Bollepalli, J. Bork-Jensen, J. Bradfield, Y. Bradford, Caroline Brandl, P. Braund, J. Brody, U. Broeckel, K. Burgdorf, B. Cade, Q. Cai, S. Camarda, A. Campbell, Marisa Cañadas-Garre, Jin-Fang Chai, A. Chesi, S. Choi, P. Christofidou, C. Couture, G. Cuéllar-Partida, Rebecca D. Danning, F. Degenhardt, G. E. Delgado, A. Delitala, A. Demirkan, Xuan Deng, Alexander Dietl, Maria Dimitriou, Latchezar Dimitrov, R. Dorajoo, F. Eichelmann, A. Eliasen, J. Engmann, M. Erdos, Z. Fairhurst-Hunter, Aliki-Eleni Farmaki, J. Faul, J. Fernández-López, L. Forer, M. Frank, Sandra Freitag-Wolf, Lars G. Fritsche, C. Fuchsberger, T. Galesloot, Yan Gao, F. Geller, O. Giannakopoulou, Franco Giulianini, A. Gjesing, A. Goel, S. Gordon, M. Gorski, J. Grove, Xiu-Qing Guo, S. Gustafsson, J. Haessler, T. Hansen, A. Havulinna, Simon Haworth, N. Heard-Costa, Daiane Hemerich, H. Highland, G. Hindy, Y. Ho, E. Hofer, Elizabeth Holliday, K. Horn, W. Hornsby, J. Hottenga, Hong-Yang Huang, Jie Huang, A. Huerta-Chagoya, Shao-Feng Huo, M. Y. Hwang, C. Hwu, Hiroyuki Iha, Daisuke D Ikeda, M. Isono, A. Jackson, I. Jansen, Yun-Xuan Jiang, Ingegerd Johansson, A. Jonsson, T. Jørgensen, I. Kalafati, M. Kanai, S. Kanoni, L. Kårhus, A. Kasturiratne, Tomohiro Katsuya, T. Kawaguchi, R. Kember, K. Kentistou, Daeeun Kim, Han-Na Kim, Young Jin Kim, M. Kleber, M. Knol, A. Kurbasic, Marie Lauzon, P. Le, Rodney Lea, Jong-Young Lee, Wen-Jane Lee, H. Leonard, Hengtong Li, Shengchao A Li, Xiaohui Li, Xiao-Ying Li, Jingjing Liang, Honghuang Lin, Kuang Lin, Jun Liu, Xueping Liu, K. Lo, J. Long, L. Lorés-Motta, J. Luan, V. Lyssenko, L. Lyytikäinen, A. Mahajan, M. Malik, Vasiliki Mamakou, Massimo Mangino, A. Manichaikul, J. Marten, M. Mattheisen, Aaron F. McDaid, Quan-Shun Mei, H. Meiselbach, Tori L. Melendez, Y. Milaneschi, Jason E. Miller, I. Millwood, Pashupati P. Mishra, R. Mitchell, L. Møllehave, N. Mononen, Sören Mucha, M. Munz, J. Mykkänen, M. Nakatochi, G. G. Nardone, Christopher P. Nelson, M. Nethander, C. Nho, A. A. Nielsen, I. Nolte, Suraj S. Nongmaithem, R. Noordam, I. Ntalla, T. Nutile, A. Pandit, M. Pauper, Eva R. B. Petersen, L. Petersen, Francesco Piluso, O. Polašek, A. Poveda, S. Pyarajan, L. Raffield, Hiromi Rakugi, Julia Ramirez, A. Rasheed, Dennis Raven, N. W. Rayner, Carlos Riveros, Rebecca R. Rohde, D. Ruggiero, S. Ruotsalainen, Kathleen A. Ryan, M. Sabater-Lleal, Aurora Santin, R. Saxena, M. Scholz, Botong Shen, Jingchunzi Shi, Jae Hun Shin, C. Sidore, J. Sidorenko, Xueling Sim, R. Slieker, Albert V. Smith, Jennifer A. Smith, L. Smyth, L. Southam, V. Steinthorsdottir, Liang Sun, F. Takeuchi, K. Taylor, B. Tayo, C. Tcheandjieu, N. Terzikhan, P. Tesolin, A. Teumer, E. Theusch, D. Thompson, G. Thorleifsson, P. R. H. J. Timmers, S. Trompet, C. Turman, Simona Vaccargiu, S. W. van der Laan, P. J. van der Most, J. V. van Klinken, J. van Setten, S. Verma, Niek Verweij, Yogasudha Veturi, Carol A. Wang, Chaolong Wang, Jun-Sing Wang, Lihua Wang, Y. X. Wang, Zhe Wang, H. Warren, Wen Bin Wei, W. Wen, William Wheeler, A. R. Wickremasinghe, M. Wielscher, B. Winsvold, A. Wong, M. Wuttke, Rui Xia, Ken Yamamoto, Jingyun Yang, Jie Yao, Hannah Young, Noha A. Yousri, Lei Yu, Lingyao Zeng, Weihua Zhang, Xinyuan Zhang, Jing-Hua Zhao, Wei Zhao, Wei Zhou, M. Zimmermann, M. Zoledziewska, L. '. ‘t Hart, Linda S. Adair, H. Adams, C. A. Aguilar-Salinas, F. Al-Mulla, Donna K. Arnett, F. Asselbergs, B. Åsvold, J. Attia, B. Banas, S. Bandinelli, L. Beilin, D. A. Bennett, T. Bergler, D. Bharadwaj, G. Biino, E. Boerwinkle, C. Böger, J. Borja, Claude Bouchard, Donald W. Bowden, Ivan Brandslund, B. Brumpton, J. Buring, M. Caulfield, J. Chambers, G. Chandak, S. Chanock, N. Chaturvedi, Yii-Der Ida Chen, Zhengming Chen, Ching-Yu Cheng, Yoon Shin Cho, Kaare Christensen, I. E. Christophersen, M. Ciullo, John Cole, Francis S. Collins, M. P. Concas, Richard S. Cooper, Miguel Cruz, Francesco Cucca, Michael J. Cutler, S. Damrauer, T. Dantoft, G. D. De Borst, E. D. de Geus, L. D. de Groot, P. De Jager, D. D. de Kleijn, H. D. de Silva, G. Dedoussis, A. D. den Hollander, Shu-Fa Du, D. Easton, K.-U. Eckardt, P. Elders, A. Eliassen, P. Ellinor, S. Elmståhl, Jeanette Erdmann, M. Evans, D. Fatkin, B. Feenstra, M. Feitosa, L. Ferrucci, Jose C. Florez, I. Ford, M. Fornage, A. Franke, P. W. Franks, B. Freedman, C. Gieger, G. Girotto, Y. Golightly, C. González-Villalpando, P. Gordon-Larsen, H. Grallert, S. Grant, N. Grarup, Lyn R. Griffiths, V. Gudnason, C. Haiman, H. Hakonarson, T. Hansen, C. Hartman, A. Hattersley, Caroline Hayward, I. Heid, C. Heng, C. Hengstenberg, Karl-Heinz Herzig, A. Hewitt, H. Hishigaki, D. Hougaard, C. Hoyng, Paul L. Huang, Wei Huang, Wen-Yi Huang, Jennifer E. Huffman, Steven C. Hunt, N. Hutri, K. Hveem, E. Hyppönen, William G. Iacono, S. Ichihara, M. Ikram, C. Isasi, M. Jarvelin, Zi‐Bing Jin, K. Jöckel, J. Jonas, Peter K. Joshi, P. Jousilahti, J. Jukema, M. Kähönen, Y. Kamatani, K. Kang, J. Kaprio, Sharon L. R. Kardia, F. Karpe, Norihiro Kato, M. Kavousi, F. Kee, Thorsten Kessler, A. Khera, C. Khor, L. Kiemeney, Bong-Jo Kim, Eung Kweon Kim, Hyung-Lae Kim, P. Kirchhof, M. Kivimaki, Woon-Puay Koh, H. Koistinen, A. Kokkinos, J. Kooner, C. Kooperberg, P. Kovács, A. Kraaijeveld, P. Kraft, Ronald M. Krauss, M. Kumari, Z. Kutalik, M. Laakso, L. Lange, C. Langenberg, L. Launer, Hyejin Lee, N. Lee, T. Lehtimäki, R. Lemaitre, Huaixing Li, Li-Ming Li, W. Lieb, Xu Lin, L. Lind, A. Linneberg, Ching-Ti Liu, Jianjun Liu, Markus Loeffler, Barry London, Fan Lu, S. Lubitz, David A. Mackey, Patrik Magnusson, J. Manson, Gregory M. Marcus, P. Marques Vidal, Nicholas G. Martin, W. Marz, F. Matsuda, M. McCarthy, Robert W. McGarrah, M. McGue, A. McKnight, S. Medland, D. Mellström, A. Metspalu, B. Mitchell, Paul Mitchell, D. Mook-Kanamori, T. Mori, A. D. Morris, L. Mucci, P. Munroe, M. Nalls, Saman Nazarian, Amanda E. Nelson, M. Neville, C. Newton-Cheh, Christopher S. Nielsen, Harri Niinikoski, Kjell C. Nikus, M. Nöthen, A. Ogunniyi, Claes Ohlsson, A. Oldehinkel, L. Orozco, K. Pahkala, P. Pajukanta, Colin N. A. Palmer, Esteban J. Parra, C. Pattaro, Oluf Pedersen, C. Pennell, B. Penninx, L. Pérusse, Annette Peters, P. Peyser, D. Porteous, D. Posthuma, Chris Power, P. Pramstaller, M. Province, B. Psaty, Q. Qi, Jia Qu, D. Rader, O. Raitakari   +499 more
semanticscholar   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Pregabalin abuse and dependence during insomnia and protocol for short-term withdrawal management with diazepam: examples from case reports [PDF]

Sleep Science
Introduction:: Pregabalin (PGN) is an anxiolytic, analgesic, antiepileptic, and hypnotic medication. There are concerns about its abuse in the community for managing chronic insomnia and other risks when assumed in overdose or combination with other ...
Basavaraja Papanna, Carlo Lazzari, Kapil Kulkarni, Sivasankar Perumal, Abdul Nusair   +4 more
doaj   +1 more source

Plasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection. [PDF]

, 2012
OBJECTIVES: The magnitude of HIV viral rebound following ART cessation has consequences for clinical outcome and onward transmission. We compared plasma viral load (pVL) rebound after stopping ART initiated in primary (PHI) and chronic HIV infection (CHI)
López-Diéguez, María, Babiker, A, Myra McClure (309188), Porter, Kholoud, Jonathan Weber (59115), Phillips, R, Pedersen, Court, Giuseppe Tambussi (237799), Jason F Okulicz (16174841), Weber, Jonathan, Tambussi, G, Weber, J, Hamlyn Elizabeth, Miró Meda, José M. (José María), 1956-, García, M. T., Abdel Babiker (225813), Hamlyn, E, Schechter, M, Pedersen Court, Court Pedersen (38784), Hamlyn, Elizabeth, Jason F Okulicz, Elizabeth Hamlyn (309179), Cooper David A., Manzardo, Christian, Tambussi, Giuseppe, McClure, Myra, Schechter, Mauro, Jonathan Weber, Babiker Abdel, Plana Prades, Montserrat, Kholoud Porter, Abdel Babiker, Cooper, David A, Kholoud Porter (252703), Emery, Sean, Okulicz Jason F., Fiona M Ewings, Cooper, DA, INSIGHT SMART, David A Cooper (16165874), Court Pedersen, SPARTAC Trial Investigators, INSIGHT SMART and SPARTAC Investigators, Phillips, Rodney, Fidler Sarah, Myra McClure, Ligero, M. C., Pedersen, C, Elizabeth Hamlyn, Pumarola Suñé, Tomàs, Tuset Creus, Montserrat, Porter, K, Schechter Mauro, McClure, M, Mauro Schechter, Babiker, Abdel, Ewings, FM, The INSIGHT SMART and SPARTAC Investigators (16174844), Martin Fisher (300134), Fidler, S, Okulicz, Jason F., McClure Myra, Arnaiz Gargallo, Juan Alberto, Cooper, David A., Giuseppe Tambussi, Sarah Fidler, Weber Jonathan, Sarah Fidler (76851), Ewings, Fiona M., Okulicz, JF, Gatell, José M., Fidler, Sarah, Okulicz, Jason F, David A Cooper, SPARTAC Investigator, Tambussi Giuseppe, Mauro Schechter (4928), INSIGHT SMART Investigator, Fiona M Ewings (16174838), Ewings Fiona M., Porter Kholoud, Gallart, Teresa, Ewings, Fiona M   +83 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source