Results 61 to 70 of about 8,719,128 (293)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Myopia progression after cessation of atropine in children: a systematic review and meta-analysis

Frontiers in Pharmacology
Purpose: To comprehensively assess rebound effects by comparing myopia progression during atropine treatment and after discontinuation.Methods: A systematic search of PubMed, EMBASE, Cochrane CENTRAL, and ClinicalTrials.gov was conducted up to 20 ...
Ssu-Hsien Lee, Ping-Chiao Tsai, Yu-Chieh Chiu, Jen-Hung Wang, Cheng-Jen Chiu, Cheng-Jen Chiu   +5 more
doaj   +1 more source

Topical lidocaine inhibits spasm during colonoscopy: a double-blind, randomized controlled trial (with video)

Endoscopy International Open, 2017
Background and study aims Topical peppermint oil prevents intestinal spasm, but can cause rebound spasm. Lidocaine hydrochloride, a local anesthetic, may work as an antispasmodic by blocking Na + channels.
Daiki Nemoto, Kenichi Utano, Noriyuki Isohata, Shungo Endo, Kensuke Kumamoto, Taka-aki Koshimizu, Alan Lefor, Kazutomo Togashi   +7 more
doaj   +1 more source

COMPARISON OF REBOUND NUMBERS FOR M20 CONCRETE WITH SILICA FUME

International Journal of Research in Engineering and Technology, 2014
The concrete is one of the most important for all the construction work. The main role of the concrete based on cement, steel. To improve the strength and durable of the concrete to add the admixture. Silica fume is added to the fresh concrete to improve the durability, ductility and strengthen of the concrete.
openaire   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Robustness analysis of on-site assessment for concrete strength based on Monte-Carlo simulation

Case Studies in Construction Materials
The strength assessment of concrete materials constitutes a critical component in the performance evaluation of existing reinforced concrete (RC) structures.
Xiaohui Yu, Qianrun Tian, Xinjiang Zhang, Wentao Wang   +3 more
doaj   +1 more source

Interaction Law for a Collision Between Two Solid Particles in a Viscous Liquid [PDF]

, 2006
This thesis addresses the problem of inter-particle collisions in a viscous liquid. Experimental measurements were made on normal and oblique collisions between identical and dissimilar pairs of solid spheres.
Yang, Fu-Ling
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Plasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection. [PDF]

, 2012
OBJECTIVES: The magnitude of HIV viral rebound following ART cessation has consequences for clinical outcome and onward transmission. We compared plasma viral load (pVL) rebound after stopping ART initiated in primary (PHI) and chronic HIV infection (CHI)
López-Diéguez, María, Babiker, A, Myra McClure (309188), Porter, Kholoud, Jonathan Weber (59115), Phillips, R, Pedersen, Court, Giuseppe Tambussi (237799), Jason F Okulicz (16174841), Weber, Jonathan, Tambussi, G, Weber, J, Hamlyn Elizabeth, Miró Meda, José M. (José María), 1956-, García, M. T., Abdel Babiker (225813), Hamlyn, E, Schechter, M, Pedersen Court, Court Pedersen (38784), Hamlyn, Elizabeth, Jason F Okulicz, Elizabeth Hamlyn (309179), Cooper David A., Manzardo, Christian, Tambussi, Giuseppe, McClure, Myra, Schechter, Mauro, Jonathan Weber, Babiker Abdel, Plana Prades, Montserrat, Kholoud Porter, Abdel Babiker, Cooper, David A, Kholoud Porter (252703), Emery, Sean, Okulicz Jason F., Fiona M Ewings, Cooper, DA, INSIGHT SMART, David A Cooper (16165874), Court Pedersen, SPARTAC Trial Investigators, INSIGHT SMART and SPARTAC Investigators, Phillips, Rodney, Fidler Sarah, Myra McClure, Ligero, M. C., Pedersen, C, Elizabeth Hamlyn, Pumarola Suñé, Tomàs, Tuset Creus, Montserrat, Porter, K, Schechter Mauro, McClure, M, Mauro Schechter, Babiker, Abdel, Ewings, FM, The INSIGHT SMART and SPARTAC Investigators (16174844), Martin Fisher (300134), Fidler, S, Okulicz, Jason F., McClure Myra, Arnaiz Gargallo, Juan Alberto, Cooper, David A., Giuseppe Tambussi, Sarah Fidler, Weber Jonathan, Sarah Fidler (76851), Ewings, Fiona M., Okulicz, JF, Gatell, José M., Fidler, Sarah, Okulicz, Jason F, David A Cooper, SPARTAC Investigator, Tambussi Giuseppe, Mauro Schechter (4928), INSIGHT SMART Investigator, Fiona M Ewings (16174838), Ewings Fiona M., Porter Kholoud, Gallart, Teresa, Ewings, Fiona M   +83 more
core   +1 more source