Results 51 to 60 of about 205,308 (302)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

De-Escalation by Reversing the Escalation with a Stronger Synergistic Package of Contact Tracing, Quarantine, Isolation and Personal Protection: Feasibility of Preventing a COVID-19 Rebound in Ontario, Canada, as a Case Study

Biology, 2020
Since the beginning of the COVID-19 pandemic, most Canadian provinces have gone through four distinct phases of social distancing and enhanced testing.
Biao Tang, Francesca Scarabel, Nicola Luigi Bragazzi, Zachary McCarthy, Michael Glazer, Yanyu Xiao, Jane M. Heffernan, Ali Asgary, Nicholas Hume Ogden, Jianhong Wu   +9 more
doaj   +1 more source

Economic Growth and the Unemployment Rate [PDF]

, 2011
[Excerpt] Despite the resumption of economic (output) growth in June 2009, the unemployment rate remains at an historically high level more than two years into the recovery from the 11th recession of the postwar period.
Levine, Linda
core   +4 more sources

Coronal rain in magnetic arcades: Rebound shocks, Limit cycles, and Shear flows

, 2015
We extend our earlier multidimensional, magnetohydrodynamic simulations of coronal rain occurring in magnetic arcades with higher resolution, grid-adaptive computations covering a much longer ($>6$ hour) timespan.
Fang, X., Keppens, R., Van Doorsselaere, T., Xia, C.   +3 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Research on Rebound Performance of Shotcrete

Advances in Civil Engineering
The current rebound rate of shotcrete is high and does not meet the support requirements in the initial stages of construction. This study investigates the rebound performance of various cementing materials by incorporating silica fume, microspheres, and
Jinli Wang, Bing Xue, Yuxuan Li, Pingchuan Lai, Linni Zhang   +4 more
doaj   +1 more source

Dynamical rearrangement of super-Earths during disk dispersal II. Assessment of the magnetospheric rebound model for planet formation scenarios

, 2017
Context.The Kepler mission has provided a large sample to statistically analyze the orbital properties of the super-Earth planets. We hypothesize that these planets formed early and consider the problem of matching planet formation theory to the current ...
Liu, Beibei, Ormel, Chris W.
core   +1 more source

State-of-the-art in studies of glacial isostatic adjustment for the British Isles: a literature review [PDF]

, 2016
Understanding the effects of glacial isostatic adjustment (GIA) of the British Isles is essential for the assessment of past and future sea-level trends.
Alistair Rennie, Arıkan, Bekaert, Bingley, Bähr, Davenport, Elizabeth J Petrie, Firth, Firth, Firth, Jardine, Jim Hansom, Julia Stockamp, Kaneko, Lambeck, Li, Li, Paul Bishop, Peltier, Plag, Ringrose, Samsonov, Shennan, Shennan, Shennan, Shennan, Sissons, Sissons, Sissons, Smith, Smith, Smith, Tong, Van de Plassche, Wang, Woodroffe, Zhenhong Li   +36 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Initial experience in self-monitoring of intraocular pressure. [PDF]

, 2020
Background/aims: Diurnal variation in intraocular pressure (IOP) is a routine assessment in glaucoma management. Providing patients the opportunity to perform self-tonometry might empower them and free hospital resource.
Dabasia, P., Farr, J., Lawrenson, J. G., McGarva, E., Murdoch, I. E.   +4 more
core   +2 more sources